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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한약리학회 The Korean Journal of Physiology & Pharmacology The Korean Journal of Physiology & Pharmacology 제25권 제5호
- 발행연도
- 2021.9
- 수록면
- 479 - 488 (10page)
- DOI
- 10.4196/kjpp.2021.25.5.479
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초록· 키워드
오류제보하기
This study aimed to develop docetaxel (DTX) loaded poly(lactic-coglycolic acid) (PLGA) nanoparticles (DTX-NPs) and to evaluate the different pharmacological sensitivity of NPs to MCF-7 and MDA-MB-231 breast cancer cells. NPs containing DTX or coumarin-6 were prepared by the nanoprecipitation method using PLGA as a polymer and d-α-tocopherol polyethylene glycol 1000 succinate (TPGS) as a surfactant. The physicochemical properties of NPs were characterized. In vitro anticancer effect and cellular uptake were evaluated in breast cancer cells. The particle size and zeta potential of the DTX-NPs were 160.5 ± 3.0 nm and ?26.7 ± 0.46 mV, respectively.
The encapsulation efficiency and drug loading were 81.3 ± 1.85% and 10.6 ± 0.24%, respectively. The in vitro release of DTX from the DTX-NPs was sustained at pH 7.4 containing 0.5% Tween 80. The viability of MDA-MB-231 and MCF-7 cells with DTX-NPs was 37.5 ± 0.5% and 30.3 ± 1.13%, respectively. The IC50 values of DTX-NPs were 3.92- and 6.75-fold lower than that of DTX for MDA-MB-231 cells and MCF-7 cells, respectively. The cellular uptake of coumarin-6-loaded PLGA-NPs in MCF-7 cells was significantly higher than that in MDA-MB-231 cells. The pharmacological sensitivity in breast cancer cells was higher on MCF-7 cells than on MDA-MB-231 cells. In conclusion, we successfully developed DTX-NPs that showed a great potential for the controlled release of DTX. DTX-NPs are an effective formulation for improving anticancer effect in breast cancer cells.
목차
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참고문헌 (4)
참고문헌 신청
Paolo Blasi / 2019 / Poly(lactic acid)/poly(lactic‑co‑glycolic acid)‑based microparticles: an overview / Journal of Pharmaceutical Investigation 49(4):337~346
Enas M. Elmowafy / 2019 / Biocompatibility, biodegradation and biomedical applications of poly(lactic acid)/poly(lactic‑co‑glycolic acid) micro and nanoparticles / Journal of Pharmaceutical Investigation 49(4):347~380
Giulia Bonacucina / 2019 / PEGylated polylactide (PLA) and poly (lactic‑co‑glycolic acid) (PLGA) copolymers for the design of drug delivery systems / Journal of Pharmaceutical Investigation 49(4):443~458
최영욱 / 2019 / Steric stabilization of RIPL peptide-conjugated liposomes and in vitro assessment / Journal of Pharmaceutical Investigation 49(1):115~125
Enas M. Elmowafy / 2019 / Biocompatibility, biodegradation and biomedical applications of poly(lactic acid)/poly(lactic‑co‑glycolic acid) micro and nanoparticles / Journal of Pharmaceutical Investigation 49(4):347~380
Giulia Bonacucina / 2019 / PEGylated polylactide (PLA) and poly (lactic‑co‑glycolic acid) (PLGA) copolymers for the design of drug delivery systems / Journal of Pharmaceutical Investigation 49(4):443~458
최영욱 / 2019 / Steric stabilization of RIPL peptide-conjugated liposomes and in vitro assessment / Journal of Pharmaceutical Investigation 49(1):115~125
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