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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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Dioscin (DS), a steroidal saponin, has been shown to have anti-cancer activity by exerting antioxidant effects and inducing apopto sis. However, the anti-cancer activity of DS in breast cancer-derived stem cells is still controversial. The purpose of this study was to evaluate the effects of DS on migration, invasion, and colony formation in MDA-MB-231 and MCF-7 cell lines and the mechanism by which it inhibits proliferation of breast cancer stem-like cells after inducing differentiation into breast cancer stem cells. DS treatment significantly reduced cellular migration, invasion, and colony formation in MDA-MB-231 and MCF-7 cells. During the differentiation process that induced manifestation of breast cancer stem-like cells, DS significantly inhibited mammosphere formation in a dose-de pendent manner and increased the expression of p53 and p21 in breast cancer stem-like cells, reducing the expression of cdc2 and cyclin B1 in MDA-MB-231 cells and cyclin D, cyclin E, CDK4, and CDK2 in MCF-7 cells. Interestingly, DS treatment induced G2/M and G0/G1 cell cycle arrest in the MDA-MB-231 and MCF-7 cells, respectively. DS also increased the phosphorylation of p38 and decreased the expression levels of p-AKT and p-mTOR. These results suggest that DS regulates the p38 mitogen-activated pro tein kinase and AKT/mTOR signaling pathways to reduce the proliferation of breast cancer stem-like cells through cell cycle arrest.
Therefore, these findings suggest that DS may serve as a potential treatment candidate targeting breast cancer stem cells.
Key Words Dioscin, Breast cancer, AKT/mTOR
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참고문헌 (41)
참고문헌 신청
Bray F / 2018 / Global cancer statistics 2018 : GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185countries / CA Cancer J Clin 68:394~424
Felipe Lima J / 2016 / EMT in breast carcinoma-a review / J Clin Med 5:65
La Belle A / 2017 / Role of platinum in early-stage triple-negative breast cancer / Curr Treat Options Oncol 18:68
Park SY / 2019 / Targeting cancer stem cells in triplenegative breast cancer / Cancers(Basel) 11:965
Frank NY / 2010 / The therapeutic promise of the cancer stem cell concept / J Clin Invest 120:41~50
Felipe Lima J / 2016 / EMT in breast carcinoma-a review / J Clin Med 5:65
La Belle A / 2017 / Role of platinum in early-stage triple-negative breast cancer / Curr Treat Options Oncol 18:68
Park SY / 2019 / Targeting cancer stem cells in triplenegative breast cancer / Cancers(Basel) 11:965
Frank NY / 2010 / The therapeutic promise of the cancer stem cell concept / J Clin Invest 120:41~50
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