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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한약리학회 The Korean Journal of Physiology & Pharmacology The Korean Journal of Physiology & Pharmacology 제21권 제1호
- 발행연도
- 2017.1
- 수록면
- 45 - 54 (10page)
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초록· 키워드
오류제보하기
Our study aims to determine the metabolism and excretion of novel pulmonary-targeting docetaxel liposome (DTX-LP) using the in vitro and in vivo animal experimental models. The metabolism and excretion of DTX-LP and intravenous DTX (DTX-IN) in New Zealand rabbits were determined with ultraperformance liquid chromatography tandem mass spectrometry. We found DTX-LP and DTX-IN were similarly degraded in vitro by liver homogenates and microsomes, but not metabolized by lung homogenates. Ultra-performance liquid chromatography tandem mass spectrometry identified two shared DTX metabolites.
The unconfirmed metabolite Mun differed structurally from all DTX metabolites identified to date. DTX-LP likewise had a similar in vivo metabolism to DTX-IN.
Conversely, DTX-LP showed significantly diminished excretion in rabbit feces or urine, approximately halving the cumulative excretion rates compared to DTXIN.
Liposomal delivery of DTX did not alter the in vitro or in vivo drug metabolism.
Delayed excretion of pulmonary-targeting DTX-LP may greatly enhance the therapeutic efficacy and reduce the systemic toxicity in the chemotherapy of nonsmall cell lung cancer. The identification of Mun may further suggest an alternative species-specific metabolic pathway.
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등록된 정보가 없습니다.
참고문헌 (29)
참고문헌 신청
Reck M / 2013 / Management of non-small-cell lung cancer : recent developments / Lancet 382:709~719
Stanisic S / 2010 / Societal cost savings through bevacizumab-based treatment in non-small cell lung cancer (NSCLC) / Lung Cancer (69 Suppl 1):S24~S30
Ando M / 2005 / Sequence effect of docetaxel and carboplatin on toxicity, tumor response and pharmacokinetics in non-small-cell lung cancer patients : a phase I study of two sequences / Cancer Chemother Pharmacol 55:552~558
Lunardi G / 2002 / Influence of alternate sequences of epirubicin and docetaxel on the pharmacokinetic behaviour of both drugs in advanced breast cancer / Ann Oncol 13:280~285
Airoldi M / 2003 / Docetaxel and vinorelbine in recurrent head and neck cancer : pharmacokinetic and clinical results / Am J Clin Oncol 26:378~381
Stanisic S / 2010 / Societal cost savings through bevacizumab-based treatment in non-small cell lung cancer (NSCLC) / Lung Cancer (69 Suppl 1):S24~S30
Ando M / 2005 / Sequence effect of docetaxel and carboplatin on toxicity, tumor response and pharmacokinetics in non-small-cell lung cancer patients : a phase I study of two sequences / Cancer Chemother Pharmacol 55:552~558
Lunardi G / 2002 / Influence of alternate sequences of epirubicin and docetaxel on the pharmacokinetic behaviour of both drugs in advanced breast cancer / Ann Oncol 13:280~285
Airoldi M / 2003 / Docetaxel and vinorelbine in recurrent head and neck cancer : pharmacokinetic and clinical results / Am J Clin Oncol 26:378~381
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