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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한약리학회 The Korean Journal of Physiology & Pharmacology The Korean Journal of Physiology & Pharmacology 제22권 제6호
- 발행연도
- 2018.11
- 수록면
- 689 - 696 (8page)
- DOI
- https://doi.org/10.4196/kjpp.2018.22.6.689
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이 논문의 연구 히스토리 (3)
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초록· 키워드
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Increasing evidence implicates changes in [Ca2+]i and oxidative stress as causative factors in amyloid beta (Aβ)-induced neuronal cell death. Cyanidin-3-glucoside (C3G), a component of anthocyanin, has been reported to protect against glutamate- induced neuronal cell death by inhibiting Ca2+ and Zn2+ signaling. The present study aimed to determine whether C3G exerts a protective effect against Aβ25-35- induced neuronal cell death in cultured rat hippocampal neurons from embryonic day 17 fetal Sprague-Dawley rats using MTT assay for cell survival, and caspase-3 assay and digital imaging methods for Ca2+, Zn2+, MMP and ROS. Treatment with Aβ25-35 (20 μM) for 48 h induced neuronal cell death in cultured rat pure hippocampal neurons. Treatment with C3G for 48 h significantly increased cell survival. Pretreatment with C3G for 30 min significantly inhibited Aβ25-35-induced [Zn2+]i increases as well as [Ca2+]i increases in the cultured rat hippocampal neurons. C3G also significantly inhibited Aβ25-35-induced mitochondrial depolarization. C3G also blocked the Aβ25-35-induced formation of ROS.
In addition, C3G significantly inhibited the Aβ25-35-induced activation of caspase-3.
These results suggest that cyanidin-3-glucoside protects against amyloid β-induced neuronal cell death by reducing multiple apoptotic signals.
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등록된 정보가 없습니다.
참고문헌 (3)
참고문헌 신청
Mohammad Iqbal Hossain Bhuiyan / 2011 / The Neuroprotective Potential of Cyanidin-3-glucoside Fraction Extracted from Mulberry Following Oxygen-glucose Deprivation / The Korean Journal of Physiology & Pharmacology 15(6):353~361
Shazia Perveen / 2014 / Cyanidin-3-glucoside Inhibits ATP-induced Intracellular Free Ca2＋ Concentration, ROS Formation and Mitochondrial Depolarization in PC12 Cells / The Korean Journal of Physiology & Pharmacology 18(4):297~305
Adam-Vizi V / 2010 / Calcium and mitochondrial reactive oxygen species generation: how to read the facts / J Alzheimers Dis 20(Suppl 2):S413~S426
Shazia Perveen / 2014 / Cyanidin-3-glucoside Inhibits ATP-induced Intracellular Free Ca2＋ Concentration, ROS Formation and Mitochondrial Depolarization in PC12 Cells / The Korean Journal of Physiology & Pharmacology 18(4):297~305
Adam-Vizi V / 2010 / Calcium and mitochondrial reactive oxygen species generation: how to read the facts / J Alzheimers Dis 20(Suppl 2):S413~S426
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