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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 426 - 432 (7page)
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초록· 키워드
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Age-related rotator cuff tendon degeneration is related to tenofibroblast apoptosis. Anthocyanins reduce oxidative stress-induced apoptotic cell death in tenofibroblasts. The current study investigated the presence of cell protective effects in cyanidin and delphinidin, the most common aglycon forms of anthocyanins. We determined whether these anthocyanidins have antiapoptotic and antinecrotic effects in tenofibroblasts exposed to $H_2O_2$, and evaluated their biomolecular mechanisms. Both cyanidin and delphinidin inhibited $H_2O_2$-induced apoptosis in a dose-dependent manner. However, at concentrations of $100{\mu}g/ml$ or greater, delphinidin showed cytotoxicity against tenofibroblasts and a decreased antinecrotic effect. Cyanidin and delphinidin both showed inhibitory effects on the $H_2O_2$-induced increase in intracellular ROS formation and the activation of ERK1/2 and JNK. In conclusion, both cyanidin and delphinidin have cytoprotective effects on cultured tenofibroblasts exposed to $H_2O_2$. These results suggest that cyanidin and delphinidin are both beneficial for the treatment of oxidative stress-mediated tenofibroblast cell death, but their working concentrations are different.
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참고문헌 (43)
참고문헌 신청
Aaby, K / 2007 / Characterization of phenolic compounds in strawberry (Fragaria x ananassa) fruits by different HPLC detectors and contribution of individual compounds to total antioxidant capacity / J. Agric. Food Chem 55:4395~4406
Arany, I / 2004 / Activation of ERK or inhibition of JNK ameliorates H2O2cytotoxicity in mouse renal proximal tubule cells / Kidney Int 65:1231~2139
Bae, Y. S / 1997 / Epidermal growth factor (EGF)-induced generation of hydrogen peroxide. Role in EGF receptor-mediated tyrosine phosphorylation / J. Biol. Chem 272:217~221
Bhat, N. R / 1999 / Hydrogen peroxide activation of multiple mitogen-activated protein kinases in an oligodendrocyte cell line: role of extracellular signal-regulated kinase in hydrogen peroxide-induced cell death / J. Neurochem 72:112~119
Bradham, C / 2006 / p38 MAPK in development and cancer / Cell Cycle 5:824~828
Arany, I / 2004 / Activation of ERK or inhibition of JNK ameliorates H2O2cytotoxicity in mouse renal proximal tubule cells / Kidney Int 65:1231~2139
Bae, Y. S / 1997 / Epidermal growth factor (EGF)-induced generation of hydrogen peroxide. Role in EGF receptor-mediated tyrosine phosphorylation / J. Biol. Chem 272:217~221
Bhat, N. R / 1999 / Hydrogen peroxide activation of multiple mitogen-activated protein kinases in an oligodendrocyte cell line: role of extracellular signal-regulated kinase in hydrogen peroxide-induced cell death / J. Neurochem 72:112~119
Bradham, C / 2006 / p38 MAPK in development and cancer / Cell Cycle 5:824~828
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