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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한약리학회 The Korean Journal of Physiology & Pharmacology The Korean Journal of Physiology & Pharmacology 제21권 제1호
- 발행연도
- 2017.1
- 수록면
- 99 - 106 (8page)
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Obesity is a critical risk factor for the hypertension. Although angiotensin II (Ang II) in obese individuals is known to be upregulated in obesity-induced hypertension, direct evidence that explains the underlying mechanism for increased vascular tone and consequent increase in blood pressure (BP) is largely unknown.
The purpose of this study is to investigate the novel mechanism underlying Ang II-induced hyper-contractility and hypertension in obese rats. Eight-week old male Sprague-Dawley rats were fed with 60% fat diet or normal diet for 4 months.
Body weight, plasma lipid profile, plasma Ang II level, BP, Ang II-induced vascular contraction, and expression of regulatory proteins modulating vascular contraction with/without Ang II stimulation were measured. As a result, high fat diet (HFD) accelerated age-dependent body weight gaining along with increased plasma Ang II concentration. It also increased BP and Ang II-induced aortic contraction. Basal expression of p-CPI-17 and myosin light chain (MLC) kinase was increased by HFD along with increased phosphorylation of MLC. Ang II-induced phosphorylation of CPI-17 and MLC were also higher in HFD group than control group. In conclusion HFD-induced hypertension is through at least in part by increased vascular contractility via increased expression and activation of contractile proteins and subsequent MLC phosphorylation induced by increased Ang II.
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참고문헌 (33)
참고문헌 신청
Abelson P / 2004 / The obesity epidemic / Science 304:1413
Mark AL / 1999 / Stateof-the-art-lecture : Obesity-induced hypertension : new concepts from the emerging biology of obesity / Hypertension 33:537~541
Goodfriend TL / 2004 / Resistant hypertension, obesity, sleep apnea, and aldosterone : theory and therapy / Hypertension 43:518~524
Gu P / 2013 / Interplay between adipose tissue and blood vessels in obesity and vascular dysfunction / Rev Endocr Metab Disord 14:49~58
Uemura K / 2006 / Influence of age and sex on high-fat dietinduced increase in blood pressure / Nagoya J Med Sci 68:109~114
Mark AL / 1999 / Stateof-the-art-lecture : Obesity-induced hypertension : new concepts from the emerging biology of obesity / Hypertension 33:537~541
Goodfriend TL / 2004 / Resistant hypertension, obesity, sleep apnea, and aldosterone : theory and therapy / Hypertension 43:518~524
Gu P / 2013 / Interplay between adipose tissue and blood vessels in obesity and vascular dysfunction / Rev Endocr Metab Disord 14:49~58
Uemura K / 2006 / Influence of age and sex on high-fat dietinduced increase in blood pressure / Nagoya J Med Sci 68:109~114
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