A Higher Angiogenin Expression is Associated With a Nonnuclear Maspin Location in Laryngeal Carcinoma

Marco Lionello; Stella Blandamura; Claudia Staffieri; Gino Marioni; Andrea Lovato; Giulia Tealdo; Luciano Giacomelli; Alberto Staffieri

추천

검색

자료유형: 학술저널

저자정보: Marco Lionello Stella Blandamura Claudia Staffieri Gino Marioni Andrea Lovato Giulia Tealdo Luciano Giacomelli Alberto Staffieri

저널정보: 대한이비인후과학회 Clinical and Experimental Otorhinolaryngology Clinical and Experimental Otorhinolaryngology 제8권 제3호

발행연도: 2015.1

수록면: 268 - 274 (7page)

이용수

📌

연구주제

📖

연구배경

🔬

연구방법

🏆

연구결과

초록· 키워드

오류제보하기

Objectives. In numerous malignancies, angiogenin (ANG) and Maspin are important proangiogenic and antiangiogenic regulators, respectively. The aim of this study was to identify potential relationships between the biological roles of these two proteins in laryngeal squamous cell carcinoma (LSCC). Methods. Immunohistochemical staining for ANG and Maspin was performed on specimens from 76 consecutive LSCC patients treated with surgery alone, considering the subcellular pattern of Maspin expression. Univariate and multivariate statistical models were used for prognostic purposes. Results. On univariate analysis, a different level of ANG expression was seen for patients stratified by subcellular Maspin expression pattern: the mean ANG expression was higher in cases with a nonnuclear MASPIN expression than in those with a nuclear pattern (P=0.002). Disease-free survival (DFS; in months) differed significantly when patients were stratified by N stage (P=0.01). Patients whose Maspin expression was nonnuclear (i.e., it was cytoplasmic or there was none) had a significantly higher recurrence rate (P<0.001), and shorter DFS (P=0.01) than those with a nuclear Maspin pattern. The mean ANG expression was significantly higher in cases with loco-regional recurrent disease (P=0.007); and patients with an ANG expression ≥5.0% had a significantly shorter DFS than those with an ANG expression <5.0% (P=0.007). On multivariate analysis, ANG expression ≥5.0% was a significant, independent, negative prognostic factor in terms of DFS (P=0.041). Conclusion. Our results support the hypothesis that a higher ANG expression is associated with a nonnuclear Maspin expression pattern in patients with LSCC. Further studies are needed to clarify the relationship between the ANG and Maspin pathways, and their potential diagnostic and therapeutic role in LSCC.

#Laryngeal Neoplasms #Angiogenin #SERPIN-B5 #Intracellular Space #Prognosis

참고문헌 (23)

참고문헌 신청

Bodenstine TM / 2012 / Maspin: molecular mechanisms and therapeutic implications / Cancer Metastasis Rev 31 (3-4) : 529 ~ 551

Gao X / 2008 / Mechanisms of action of angiogenin / Acta Biochim Biophys Sin (Shanghai) 40 (7) : 619 ~ 624

Gurzu S / 2013 / Molecular classification of colorectal cancer: a dream that can become a reality / Rom J Morphol Embryol 54 (2) : 241 ~ 245

Howlader N / / SEER cancer statistics review, 1975-2010

Kishimoto K / 2005 / Endogenous angiogenin in endothelial cells is a general requirement for cell proliferation and angiogenesis / Oncogene 24 (3) : 445 ~ 456

함께 읽어보면 좋을 논문

논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!