지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한약리학회 The Korean Journal of Physiology & Pharmacology The Korean Journal of Physiology & Pharmacology 제22권 제2호
- 발행연도
- 2018.3
- 수록면
- 127 - 134 (8page)
- DOI
- https://doi.org/10.4196/kjpp.2018.22.2.127
이용수
초록· 키워드
오류제보하기
Myofibrillogenesis regulator-1 (MR-1) is a novel protein involved in cellular proliferation, migration, inflammatory reaction and signal transduction. However, little information is available on the relationship between MR-1 expression and the progression of atherosclerosis. Here we report atheroprotective effects of silencing MR-1 in a model of Ang II-accelerated atherosclerosis, characterized by suppression focal adhesion kinase (FAK) and nuclear factor kappaB (NF-κB) signaling pathway, and atherosclerotic lesion macrophage content. In this model, administration of the siRNA-MR-1 substantially attenuated Ang II-accelerated atherosclerosis with stabilization of atherosclerotic plaques and inhibited FAK, Akt, mammalian target of rapamycin (mTOR) and NF-kB activation, which was associated with suppression of inflammatory factor and atherogenic gene expression in the artery. In vitro studies demonstrated similar changes in Ang II-treated vascular smooth muscle cells (VSMCs) and macrophages: siRNA-MR-1 inhibited the expression levels of proinflammatory factor. These studies uncover crucial proinflammatory mechanisms of Ang II and highlight actions of silencing MR-1 to inhibit Ang II signaling, which is atheroprotective.
목차
등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
Dong X / 2013 / Inhibition of PTEN expression and activity by angiotensin II induces proliferation and migration of vascular smooth muscle cells / J Cell Biochem 114:174~182
Bihl JC / 2015 / Angiotensin-(1-7) counteracts the effects of Ang II on vascular smooth muscle cells, vascular remodeling and hemorrhagic stroke: Role of the $NF{\kappa}B$ inflammatory pathway / Vascul Pharmacol 73:115~123
Moraes JA / 2015 / Alpha1beta1 and integrin-linked kinase interact and modulate angiotensin II effects in vascular smooth muscle cells / Atherosclerosis 243:477~485
Zhang F / 2016 / Angiotensin-(1-7) abrogates angiotensin II-induced proliferation, migration and inflammation in VSMCs through inactivation of ROS-mediated PI3K/Akt and MAPK/ERK signaling pathways / Sci Rep 6:34621
Fitzgibbons TP / 2016 / Emerging evidence for beneficial macrophage functions in atherosclerosis and obesity-induced insulin resistance / J Mol Med (Berl) 94:267~275
Bihl JC / 2015 / Angiotensin-(1-7) counteracts the effects of Ang II on vascular smooth muscle cells, vascular remodeling and hemorrhagic stroke: Role of the
Moraes JA / 2015 / Alpha1beta1 and integrin-linked kinase interact and modulate angiotensin II effects in vascular smooth muscle cells / Atherosclerosis 243:477~485
Zhang F / 2016 / Angiotensin-(1-7) abrogates angiotensin II-induced proliferation, migration and inflammation in VSMCs through inactivation of ROS-mediated PI3K/Akt and MAPK/ERK signaling pathways / Sci Rep 6:34621
Fitzgibbons TP / 2016 / Emerging evidence for beneficial macrophage functions in atherosclerosis and obesity-induced insulin resistance / J Mol Med (Berl) 94:267~275
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Angiotensin II Modulates p130Cas of Podocytes by the Suppression of AMP-Activated Protein Kinase
Journal of Korean Medical Science
2016 .01
-
High fat diet confers vascular hyper-contractility against angiotensin II through upregulation of MLCK and CPI-17
The Korean Journal of Physiology & Pharmacology
2017 .01
-
Angiotensin II Type 1 Receptor Blocker, Fimasartan, Reduces Vascular Smooth Muscle Cell Senescence by Inhibiting the CYR61 Signaling Pathway
Korean Circulation Journal
2019 .01
-
Expressions and Clinical Significances of Angiopoietin-1, Angiopoietin-2, and Tie-2 Receptor in Patients With Colorectal Cancer
Annals of Coloproctology
2017 .01
-
Angiotensin II induces endoplasmic reticulum stress in podocyte, which would be further augmented by PI3-kinase inhibition
Clinical Hypertension
2015 .01
-
Glucagon-Like Peptide Receptor Agonist Inhibits Angiotensin II-Induced Proliferation and Migration in Vascular Smooth Muscle Cells and Ameliorates Phosphate-Induced Vascular Smooth Muscle Cells Calcification
Diabetes and Metabolism Journal
2024 .01
-
Superoxide Dismutase Activity in Small Mesenteric Arteries Is Downregulated by Angiotensin II but Not by Hypertension
Toxicological Research
2018 .10
-
Deciphering Macrophage Phenotypes upon Lipid Uptake and Atherosclerosis
Immune Network
2020 .06
-
Roles of immune cell in the cardiovascular diseases
한국실험동물학회 학술발표대회 논문집
2021 .07
-
Regulation of Macrophage Activation and Differentiation in Atherosclerosis
지질·동맥경화학회지
2021 .09
-
Sulfatase 1 mediates the inhibitory effect of angiotensin II type 2 receptor inhibitor on angiotensin II-induced hypertensive mediator expression and proliferation in vascular smooth muscle cells from spontaneously hypertensive rats
영남의대학술지
2017 .01
-
The Roles of CD137 Signaling in Atherosclerosis
Korean Circulation Journal
2016 .01
-
Sulfatase 1 mediates the inhibitory effect of angiotensin II type 2 receptor inhibitor on angiotensin II-induced hypertensive mediator expression and proliferation in vascular smooth muscle cells from spontaneously hypertensive rats
Journal of Yeungnam Medical Science
2017 .01
-
Intracranial Atherosclerosis: Where Are We Now?
대한뇌졸중학회지
2017 .01
-
Upregulation of NADH/NADPH oxidase 4 by angiotensin II induces podocyte apoptosis
Kidney Research and Clinical Practice
2023 .03
-
Functional roles and mechanisms of ginsenosides from Panax ginseng in atherosclerosis
Journal of Ginseng Research
2021 .01
-
Molecular imaging of atherosclerosis using reporter gene system
대한방사성의약품학회지
2018 .01
-
Development of Advanced Atherosclerotic Plaque by Injection of Inflammatory Proteins in a Rabbit Iliac Artery Model
Yonsei Medical Journal
2016 .01
-
The association between age-related hearing loss and atherosclerosis: animal and human population-based study
한국실험동물학회 학술발표대회 논문집
2019 .07
-
Differential Regulation of NF-κB Signaling during Human Cytomegalovirus Infection
JOURNAL OF BACTERIOLOGY AND VIROLOGY
2015 .06
이 논문의 저자 정보
최근 본 자료
댓글(0)
0