지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한약리학회 The Korean Journal of Physiology & Pharmacology The Korean Journal of Physiology & Pharmacology 제22권 제4호
- 발행연도
- 2018.7
- 수록면
- 447 - 456 (10page)
- DOI
- https://doi.org/10.4196/kjpp.2018.22.4.447
이용수
초록· 키워드
오류제보하기
Angiotensin-(1-9) [Ang-(1-9)], generated from Ang I by Ang II converting enzyme 2, has been reported to have protective effects on cardiac and vascular remodeling. However, there is no report about the effect of Ang-(1-9) on pulmonary hypertension. The aim of the present study is to investigate whether Ang-(1-9) improves pulmonary vascular remodeling in monocrotaline (MCT)-induced pulmonary hypertensive rats. Sprague-Dawley rats received Ang-(1-9) (576 μg/kg/day) or saline via osmotic mini-pumps for 3 weeks. Three days after implantation of osmotic mini-pumps, 50 mg/kg MCT or vehicle were subcutaneously injected. MCT caused increases in right ventricular weight and systolic pressure, which were reduced by co-administration of Ang-(1-9). Ang-(1-9) also attenuated endothelial damage and medial hypertrophy of pulmonary arterioles as well as pulmonary fibrosis induced by MCT. The protective effects of Ang-(1-9) against pulmonary hypertension were inhibited by Ang type 2 receptor (AT2R) blocker, but not by Mas receptor blocker. Additionally, the levels of LDH and inflammatory cytokines, such as TNF-α, MCP-1, IL-1β, and IL-6, in plasma were lower in Ang-(1-9) co-treated MCT group than in vehicle-treated MCT group. Changes in expressions of apoptosis-related proteins such as Bax, Bcl- 2, Caspase-3 and -9 in the lung tissue of MCT rats were attenuated by the treatment with Ang-(1-9). These results indicate that Ang-(1-9) improves MCT-induced pulmonary hypertension by decreasing apoptosis and inflammatory reaction via AT2R.
목차
등록된 정보가 없습니다.
참고문헌 (34)
참고문헌 신청
Rabinovitch M / 2008 / Molecular pathogenesis of pulmonary arterial hypertension / J Clin Invest 118:2372~2379
Marshall RP / 2003 / The pulmonary renin-angiotensin system / Curr Pharm Des 9:715~722
Flores-Munoz M / 2012 / Angiotensin-(1-9) attenuates cardiac fibrosis in the stroke-prone spontaneously hypertensive rat via the angiotensin type 2 receptor / Hypertension 59:300~307
Ocaranza MP / 2014 / Angiotensin-(1-9) reverses experimental hypertension and cardiovascular damage by inhibition of the angiotensin converting enzyme/Ang II axis / J Hypertens 32:771~783
Ocaranza MP / 2011 / Rho kinase inhibition activates the homologous angiotensin-converting enzyme-angiotensin-(1-9) axis in experimental hypertension / J Hypertens 29:706~715
Marshall RP / 2003 / The pulmonary renin-angiotensin system / Curr Pharm Des 9:715~722
Flores-Munoz M / 2012 / Angiotensin-(1-9) attenuates cardiac fibrosis in the stroke-prone spontaneously hypertensive rat via the angiotensin type 2 receptor / Hypertension 59:300~307
Ocaranza MP / 2014 / Angiotensin-(1-9) reverses experimental hypertension and cardiovascular damage by inhibition of the angiotensin converting enzyme/Ang II axis / J Hypertens 32:771~783
Ocaranza MP / 2011 / Rho kinase inhibition activates the homologous angiotensin-converting enzyme-angiotensin-(1-9) axis in experimental hypertension / J Hypertens 29:706~715
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Upregulation of NADH/NADPH oxidase 4 by angiotensin II induces podocyte apoptosis
Kidney Research and Clinical Practice
2023 .03
-
Comparative effects of angiotensin II and angiotensin-(4-8) on blood pressure and ANP secretion in rats
The Korean Journal of Physiology & Pharmacology
2017 .11
-
Chronic Thromboembolic Pulmonary Hypertension: Endovascular Treatment
Korean Circulation Journal
2019 .01
-
Management of Hypertension in Fabry Disease
Electrolytes & Blood Pressure
2023 .06
-
Angiotensin II Receptor Blocker Fetopathy with Persistent Pulmonary Hypertension, Hypocalvaria, Nephrogenic Diabetes Insipidus, Transient Pseudohypoaldosteronism and Polycythemia
Perinatology
2021 .01
-
New Therapeutic Target for Pulmonary Arterial Hypertension
Korean Circulation Journal
2018 .01
-
Central extracorporeal membrane oxygenation and early rehabilitation for persistent severe pulmonary hypertension following pulmonary endarterectomy
Acute and Critical Care
2019 .01
-
How to Determine Right Ventricular Dysfunction in Pulmonary Hypertension
Journal of Cardiovascular Imaging
2021 .01
-
Gene expression profiling of pulmonary hypertensive lungs and pulmonary arteries
한국실험동물학회 학술발표대회 논문집
2019 .01
-
Current Trends and Movements in Managing Pulmonary Arterial Hypertension in Korea
Korean Circulation Journal
2023 .05
-
선천성 횡격막 탈장을 제외한 폐형성장애의 자연 경과와 예후 인자
Allergy Asthma & Respiratory Diseases
2020 .01
-
Pulmonary hypertension in chronic kidney disease: what could change the fate?
Kidney Research and Clinical Practice
2016 .01
-
Trichostatin A inhibits Angiotensin II-induced Hypertension in Vasocontraction And Blood Pressure via Inhibiting of p66shc and Reactive Oxygen Species
한국실험동물학회 학술발표대회 논문집
2015 .08
-
Selective inhibition of histone deacetylase 8 improves vascular hypertrophy, relaxation, and inflammation in angiotensin II hypertensive mice
Clinical Hypertension
2019 .01
-
Pulmonary Tumor Thrombotic Microangiopathy: An Under-Recognized Potentially Fatal Cause of Pulmonary Hypertension
Korean Circulation Journal
2023 .03
-
2018 Korean Society of Hypertension guidelines for the management of hypertension: part I-epidemiology of hypertension
Clinical Hypertension
2019 .01
-
Stem Cell and Exosome Therapy in Pulmonary Hypertension
Korean Circulation Journal
2022 .02
-
Hypertension, renin-angiotensin-aldosterone-system-blocking agents, and COVID-19
Clinical Hypertension
2021 .07
-
A Case of Computed Tomography Angiography Imaging of Chronic Thromboembolic Pulmonary Hypertension Secondary to Patent Ductus Arteriosus
Cardiovascular Imaging Asia
2023 .04
-
Hyponatremia Associated with Pulmonary Arterial Hypertension: Syndrome of Inappropriate Antidiuresis Versus Right Heart Failure
Electrolytes & Blood Pressure
2020 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0