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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 1 - 7 (7page)
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Introduction: Angiotensin II (Ang II) contributes to the pathological process of vascular structures, including renal glomeruli by hemodynamic and nonhemodynamic direct effects. On renal effects, Ang II plays an important role in the development of proteinuria and glomerulosclerosis by the modification of podocyte molecules and cell survival.
In the present study, we investigated the effect of Ang II on endoplasmic reticulum (ER) stress in podocytes.
Methods: We cultured mouse podocytes with increasing doses of Ang II and evaluated ER stress markers by Western blotting.
Results: Ang II increased Bip protein, an ER chaperone, in a dose-dependent manner at 24 h, which was ameliorated by losartan, an angiotensin II type 1 receptor antagonist. Ang II also increased ER stress markers, such as phospho-PERK, phospho-eIF2α, and ATF4 proteins of podocyte, significantly in a dose-dependent manner at 24 h. Increased phospho-PERK and ATF4 proteins were further augmented by phosphoinositide 3 (PI3)-kinase inhibitor, LY294002, which suggested that Ang II could induce podocyte ER stress of PERK-eIF2α-ATF4 axis via PI3-kinase pathway.
Discussion: These studies suggest that Ang II could induce podocyte ER stress of PERK-eIF2α-ATF4 axis via PI3-kinase pathway, which would contribute to the development of podocyte injury induced by Ang II, and the augmentation of PI3-kinase would be a therapeutic target.
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참고문헌 (25)
참고문헌 신청
Aros C. / 2002 / The renin-angiotensin system in progression, remission and regression of chronic nephropathies / J Hypertens. 20 : S45 ~ S53
Asanuma K. / 2003 / The role of podocytes in glomerular pathobiology / Clin Exp Nephrol 7 : 255 ~ 259
Bek MF. / 2006 / Expression and function of C/EBP homology protein(GADD153)in podocytes / Am J Pathol 168 : 20 ~ 32
Chen YM. / 2013 / Laminin β2gene missense mutation produces endoplasmic reticulum stress in podocytes / J Am Soc Nephrol 24 : 1223 ~ 1233
Chiang CK. / 2010 / Glomerular diseases : genetic causes and future therapeutics / Nat Rev Nephrol 6 : 539 ~ 554
Asanuma K. / 2003 / The role of podocytes in glomerular pathobiology / Clin Exp Nephrol 7 : 255 ~ 259
Bek MF. / 2006 / Expression and function of C/EBP homology protein(GADD153)in podocytes / Am J Pathol 168 : 20 ~ 32
Chen YM. / 2013 / Laminin β2gene missense mutation produces endoplasmic reticulum stress in podocytes / J Am Soc Nephrol 24 : 1223 ~ 1233
Chiang CK. / 2010 / Glomerular diseases : genetic causes and future therapeutics / Nat Rev Nephrol 6 : 539 ~ 554
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Pathogenesis of Focal Segmental Glomerulosclerosis
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