지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국약제학회 Journal of Pharmaceutical Investigation Journal of Pharmaceutical Investigation 제47권 제5호
- 발행연도
- 2017.9
- 수록면
- 413 - 427 (15page)
이용수
초록· 키워드
오류제보하기
Anthocyanin has been proven to impart several health benefits and biological functions. Though, various analytical methods have been reported for single/multicomponent analysis of anthocyanins, found to be tedious, time consuming and difficult to reproduce. Analytical studies on specific anthocyanins for estimation using an approach of Analytical Quality by Design are scarce. USP method is only reliable for cyanidin-3-O-glucoside (CY-3- O-Glu) estimation, but exploring many disadvantage of having high buffer concentration in mobile phase system and gradient elution, hence column blockage. So there is need to develop a novel HPLC method to overcome this problem with the use organic solvents with lesser volume of buffer in isocratic mode of elution. The aim is to develop a robust and precise method for estimation of CY-3-O-Glu in biopolymer based microcapsules and tablets. The optimized method consisted of mobile phase containing solvent A and B, flow rate 0.8 mL/min with 20 min of analysis time. The method was further validated in accordance with current ICH guidelines Q2 (R1) and found to be highly selective for component in the presence of degradation products confirmed by Mass spectra. Therefore, the proposed method was found to be suitable for routine analysis of CY-3-O-Glu in food and pharmaceutical based formulations.
목차
등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
Beg S / 2015 / Development and validation of a stability-indicating liquid chromatographic method for estimating olmesartan medoxomil using quality by design / J Chromatogr Sci
Devi PS / 2012 / he effects of and pH on stability of anthocyanins from red sorghum (Sorghum bicolor) bran / African J Food Sci 6:567~573
Du Q / 2008 / Industrial preparation of cyanidin-3-glucoside from the fruits of Myrica rubra using slow rotary countercurrent chromatography / Int J Appl Res Nat Prod 1:1~5
Ferreira SLC / 2007 / Statistical designs and response surface techniques for the optimization of chromatographic systems / J Chromatogr A 1158:2~14
Gouvea ACMS / 2012 / Anthocyanins standards (cyanidin-3-O-glucoside and cyanidin-3-Orutinoside)isolation from freeze-dried acai (Euterpe oleraceae Mart.) by HPLC / Cienc e Tecnol Aliment 32:43~46
Devi PS / 2012 / he effects of and pH on stability of anthocyanins from red sorghum (Sorghum bicolor) bran / African J Food Sci 6:567~573
Du Q / 2008 / Industrial preparation of cyanidin-3-glucoside from the fruits of Myrica rubra using slow rotary countercurrent chromatography / Int J Appl Res Nat Prod 1:1~5
Ferreira SLC / 2007 / Statistical designs and response surface techniques for the optimization of chromatographic systems / J Chromatogr A 1158:2~14
Gouvea ACMS / 2012 / Anthocyanins standards (cyanidin-3-O-glucoside and cyanidin-3-Orutinoside)isolation from freeze-dried acai (Euterpe oleraceae Mart.) by HPLC / Cienc e Tecnol Aliment 32:43~46
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Rapid Isolation of Cyanidin 3-Glucoside and Peonidin 3-Glucoside from Black Rice (Oryza sativa) Using High-Performance Countercurrent Chromatography and Reversed-Phase Column Chromatography
Natural Product Sciences
2015 .03
-
Isolation and Development of Quantification Method for Cyanidin-3-Glucoside and Cyanidin-3-Rutinoside in Mulberry Fruit by High-Performance Countercurrent Chromatography and High-Performance Liquid Chromatography
Natural Product Sciences
2015 .03
-
Protective effect of Cyanidin 3-O-glucoside on the acetaminophen-induced hepatotoxicity in rats
한국실험동물학회 학술발표대회 논문집
2018 .01
-
Application of QbD based approach in method development of RP-HPLC for simultaneous estimation of antidiabetic drugs in pharmaceutical dosage form
Journal of Pharmaceutical Investigation
2017 .05
-
Comparative Proteome Analysis of Cyanidin 3-O-glucoside Treated Helicobacter pylori
대한의생명과학회지
2015 .12
-
Cyanidin-3-glucoside inhibits amyloid β25-35-induced neuronal cell death in cultured rat hippocampal neurons
The Korean Journal of Physiology & Pharmacology
2018 .11
-
Quality by Design (QbD) application for the pharmaceutical development process
Journal of Pharmaceutical Investigation
2022 .11
-
A quality by design approach in oral extended release drug delivery systems: where we are and where we are going?
Journal of Pharmaceutical Investigation
2023 .03
-
NF-κB억제를 통한 淸心凉膈散의 항염증 효과
한방안이비인후피부과학회지
2019 .01
-
An Exploration of the Oryza sativa L. Cyanidin-3-glucoside on the Cognitive Function in Older Adults with Subjective Memory Impairment
PSYCHIATRY INVESTIGATION
2019 .01
-
HPLC/DAD Method Validation of 6-Hydroxyluteolin 7-O-Glucoside Analysis from Salvia plebeia
생약학회지(Korean Journal of Pharmacognosy)
2021 .09
-
미나리 추출물의 기능성 원료 표준화를 위한 지표성분으로서 Hyperoside, Quercetin 3-glucoside의 분석법 검증
생약학회지(Korean Journal of Pharmacognosy)
2024 .12
-
Pharmacokinetic properties of monotropein, kaempferol 3-O-glucoside and quercetin 4"-O-glucoside after oral and intravenous gavage of MOTILIPERM in rats
한국실험동물학회 학술발표대회 논문집
2019 .07
-
사례를 통해 알아보는 QbD(Quality by Design: 의약품 설계기반 품질 고도화 시스템)
KPBMA Brief
2019 .07
-
Luteolin 5-O-glucoside from Korean Milk Thistle, Cirsium maackii, Exhibits Anti-Inflammatory Activity via Activation of the Nrf2/HO-1 Pathway
Natural Product Sciences
2017 .09
-
스마트공장과 QbD를 통해 본 제약바이오 혁신
KPBMA Brief
2022 .12
-
Evaluation of Haemagglutinin Content by RP-HPLC to Generate Pandemic Influenza Vaccine
Toxicological Research
2016 .10
-
기능성 원료 인정을 위한 제출자료 작성 가이드[민원인 안내서]에 따른 개똥숙 열수추출분말의 Scopoletin 분석을 위한 HPLC 분석법 밸리데이션
생약학회지(Korean Journal of Pharmacognosy)
2020 .03
-
Analytical Quality by Design Methodology Approach for Simultaneous Quantitation of Paeoniflorin and Decursin in Herbal Medicine by RP-HPLC Analysis
Natural Product Sciences
2021 .12
-
Inhibition of Adipocyte Differentiation by Anthocyanins Isolated from the Fruit of Vitis coignetiae Pulliat is Associated with the Activation of AMPK Signaling Pathway
Toxicological Research
2018 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0