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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 11 - 23 (13page)
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Objectives : The purpose of this study is to investigate the anti-inflammatory effect of Cheongsimyanggyeoksan(CYS) water extract in vitro and in vivo. Methods : To evaluate the anti-inflammatory effect of CYS, Raw 264.7 cells were pretreated with 3-300㎍/㎖ of CYS for 1h, and then exposed to 1㎍/㎖ of LPS. The cell viability was detected by MTT assay. Productions of nitric oxide(NO) and pro-inflammatory cytokines were measured in culture media. Protein levels of inducible nitric oxide synthase(iNOS) and Nuclear factor-κB(NF-κB) were determined by immunoblot analysis. The effect of CYS on acute inflammation in vivo was evaluated thorugh measurment of carrageenan-induced paw edema. Results : In vitro study, cell viability assay CYS treatment of 3-300㎍/㎖ has no cytotoxicity in Raw 264.7 cells. LPS-induced NO production was significantly inhibited by pretreatment with 30-300㎍/㎖ of CYS. Production of interleukin-6, -1β and tumor necrosis factor-α by LPS were significantly decreased by CYS pretreatment. CYS reduced LPS-mediated iNOS expression. Moreover, CYS significantly induced I-κBα expression and reduced NF-κB expression. In vivo study, CYS significantly reduced the increases of paw swelling. Conclusions : These results suggest the clinical basis of CYS for the treatment of inflammatory diseases.
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참고문헌 (22)
참고문헌 신청
Wang SX / 1996 / Onyeolgyeongwi / Chinese medicine publisher :231
The Association of Korean Herbal Formulation Professors / 2012 / Herbal Formulation / Younglimsa :182~184
College of Oriental Medicine Compilation Committee of Herbal medicine / 2009 / Herbal medicine / Younglimsa Press :199~200
Roh SS / 2013 / The primary color of ophthalmootolaryngology / IBCcorporation :783
Jiang YG / 2001 / 50 Cases of Laryngeal Disease with Cheongsimyanggyeok-sangamibang / Journal of Sichuan Traditional Chinese Medicine 19(11):65
The Association of Korean Herbal Formulation Professors / 2012 / Herbal Formulation / Younglimsa :182~184
College of Oriental Medicine Compilation Committee of Herbal medicine / 2009 / Herbal medicine / Younglimsa Press :199~200
Roh SS / 2013 / The primary color of ophthalmootolaryngology / IBCcorporation :783
Jiang YG / 2001 / 50 Cases of Laryngeal Disease with Cheongsimyanggyeok-sangamibang / Journal of Sichuan Traditional Chinese Medicine 19(11):65
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