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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 13 - 21 (9page)
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초록· 키워드
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Anthocyanins are naturally occurring water-soluble polyphenolic pigments in plants that have been shown to protect against cardiovascular diseases, and certain cancers, as well as other chronic human disorders. However, the anti-obesity effects of anthocyanins are not fully understood. In this study, we investigated the effects of anthocyanins isolated from the fruit of Vitis coignetiae Pulliat on the adipogenesis of 3T3-L1 preadipocytes. Our data indicated that anthocyanins attenuated the terminal differentiation of 3T3-L1 preadipocytes, as confirmed by a decrease in the number of lipid droplets, lipid content, and triglyceride production. During this process, anthocyanins effectively enhanced the activation of the AMP-activated protein kinase (AMPK); however, this phenomenon was inhibited by the co-treatment of compound C, an inhibitor of AMPK. Anthocyanins also inhibited the expression of adipogenic transcription factors, including peroxisome proliferator-activated receptor-γ, CCAAT/enhancer-binding protein a and b, and sterol regulatory element-binding protein-1c. In addition, anthocyanins were found to potently inhibit the expression of adipocyte-specific genes, including adipocyte fatty acid-binding protein, leptin, and fatty acid synthase. These results indicate that anthocyanins have potent anti-obesity effects due to the inhibition of adipocyte differentiation and adipogenesis, and thus may have applications as a potential source for an anti-obesity functional food agent.
목차
Abstract
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (38)
참고문헌 신청
Fruhbeck, G. / 2014 / Regulation of adipocyte lipolysis / Nutr. Res. Rev. 27:63~93
Berk, P.D. / 2016 / Nonalcoholic fatty liver disease: lipids and insulin resistance / Clin. Liver Dis. 20:245~262
Ali, A.T. / 2013 / Adipocyte and adipogenesis / Eur. J. Cell Biol. 92:229~236
Mota de Sa, P. / 2017 / Transcriptional regulation of adipogenesis / Compr. Physiol. 7:635~674
Guo, L. / 2015 / Transcriptional regulation of adipocyte differentiation: a central role for CCAAT/enhancer-binding protein (C/EBP) $\beta$ / J. Biol. Chem. 290:755~761
Berk, P.D. / 2016 / Nonalcoholic fatty liver disease: lipids and insulin resistance / Clin. Liver Dis. 20:245~262
Ali, A.T. / 2013 / Adipocyte and adipogenesis / Eur. J. Cell Biol. 92:229~236
Mota de Sa, P. / 2017 / Transcriptional regulation of adipogenesis / Compr. Physiol. 7:635~674
Guo, L. / 2015 / Transcriptional regulation of adipocyte differentiation: a central role for CCAAT/enhancer-binding protein (C/EBP)
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UCI(KEPA) : I410-ECN-0101-2018-513-001743692