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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.3
- 수록면
- 1 - 7 (7page)
- DOI
- 10.1038/s12276-021-00581-3
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초록· 키워드
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N6-methyladenosine (m 6 A) is the most prevalent modification of mammalian cellular RNAs. m 6 A methylation is linked to epigenetic regulation of several aspects of gene expression, including RNA stability, splicing, nuclear export, RNA folding, and translational activity. m 6 A modification is reversibly catalyzed by methyltransferases (m 6 A writers) and demethylases (m 6 A erasers), and the dynamics of m 6 A-modified RNA are regulated by m 6 A-binding proteins (m 6 A readers). Recently, several studies have shown that m 6 A methylation sites have been identified in hepatitis B virus (HBV) transcripts and the hepatitis C virus (HCV) RNA genome. Here, we review the role of m 6 A modification in HBV/HCV replication and its contribution to liver disease pathogenesis. A better understanding of the functions of m 6 A methylation in the life cycles of HBV and HCV is required to establish the role of these modifications in liver diseases associated with these viral infections.
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