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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.1
- 수록면
- 89 - 97 (9page)
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초록· 키워드
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Post-transcriptional regulation is an indispensable cellular mechanism of gene expression control that dictates various cellular functions and cell fate decisions. Recently, various chemical RNA modifications, termed the "epitranscriptome," have been proposed to play crucial roles in the regulation of post-transcriptional gene expression. To date, more than 170 RNA modifications have been identified in almost all types of RNA. As with DNA modification-mediated control of gene expression, regulation of gene expression via RNA modification is also accomplished by three groups of proteins: writers, readers, and erasers. Several emerging studies have revealed that dysregulation in RNA modification is closely associated with tumorigenesis. Notably, the molecular outcomes of specific RNA modifications often have opposite cellular consequences. In this review, we highlight the current progress in the elucidation of the mechanisms of cancer development due to chemical modifications of various RNA species.
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참고문헌 (56)
참고문헌 신청
Chen XX / 2020 / METTL14-mediated N6-methyladenosine modification of SOX4 mRNA inhi-bits tumor metastasis in colorectal cancer / Mol Cancer 19:106
Gu CH / 2019 / Mettl14inhibits bladder TIC self-renewal and bladder tumorige-nesis through N-6-methyladenosine of Notch1 / Mol Cancer 18:168
Yang X / 2020 / METTL14 suppresses proliferation and metastasis of colorectal cancer by down-regulating oncogenic long non-coding RNA XIST / Mol Cancer 19:46
Cohn WE / 1951 / Nucleoside-5’-phosphates from ribonucleic acid / Nature 167:483~484
Schwartz S / 2014 / Transcriptome-wide mapping reveals widespread dyna-mic-regulated pseudouridylation of ncRNA and mRNA / Cell 159:148~162
Gu CH / 2019 / Mettl14inhibits bladder TIC self-renewal and bladder tumorige-nesis through N-6-methyladenosine of Notch1 / Mol Cancer 18:168
Yang X / 2020 / METTL14 suppresses proliferation and metastasis of colorectal cancer by down-regulating oncogenic long non-coding RNA XIST / Mol Cancer 19:46
Cohn WE / 1951 / Nucleoside-5’-phosphates from ribonucleic acid / Nature 167:483~484
Schwartz S / 2014 / Transcriptome-wide mapping reveals widespread dyna-mic-regulated pseudouridylation of ncRNA and mRNA / Cell 159:148~162
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