지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.12
- 수록면
- 1 - 13 (13page)
- DOI
- 10.1038/s12276-020-00538-y
이용수
초록· 키워드
오류제보하기
Gastric cancer (GC) patients develop malignant ascites as the disease progresses owing to peritoneal metastasis. GC patients with malignant ascites have a rapidly deteriorating clinical course with short survival following the onset of malignant ascites. Better optimized treatment strategies for this subset of patients are needed. To define the cellular characteristics of malignant ascites of GC, we used single-cell RNA sequencing to characterize tumor cells and tumor-associated macrophages (TAMs) from four samples of malignant ascites and one sample of cerebrospinal fluid. Reference transcriptomes for M1 and M2 macrophages were generated by in vitro differentiation of healthy blood-derived monocytes and applied to assess the inflammatory properties of TAMs. We analyzed 180 cells, including tumor cells, macrophages, and mesothelial cells. Dynamic exchange of tumor-promoting signals, including the CCL3?CCR1 or IL1B?IL1R2 interactions, suggests macrophage recruitment and anti-inflammatory tuning by tumor cells. By comparing these data with reference transcriptomes for M1-type and M2-type macrophages, we found noninflammatory characteristics in macrophages recovered from the malignant ascites of GC. Using public datasets, we demonstrated that the single-cell transcriptome-driven M2-specific signature was associated with poor prognosis in GC. Our data indicate that the anti-inflammatory characteristics of TAMs are controlled by tumor cells and present implications for treatment strategies for GC patients in which combination treatment targeting cancer cells and macrophages may have a reciprocal synergistic effect.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Nanocomplex-Mediated in vivo CAR-M1 Macrophage Therapy for Solid Tumors
한국고분자학회 학술대회 연구논문 초록집
2021 .10
-
Adrenergic receptor β2 activation by stress promotes breast cancer progression through macrophages M2 polarization in tumor microenvironment
BMB Reports
2015 .01
-
Label-Free and Real-Time Electrical Impedance Monitoring of Macrophage Polarization of THP-1 Monocytes on Indium Tin Oxide Electrode
BioChip Journal
2024 .03
-
Lipid-based Particles with Specific Macrophage Accumulation Capability for the Treatment of Inflammatory Diseases
한국생물공학회 학술대회
2022 .09
-
MAPK4 silencing in gastric cancer drives liver metastasis by positive feedback between cancer cells and macrophages
Experimental and Molecular Medicine
2023 .02
-
Implantable ascites drainage stent designs and experiments to improve the quality of life in terminal cancer patients
Journal of Advanced Marine Engineering and Technology (JAMET)
2021 .10
-
Engineered Macrophage via Click Chemistry Enhances Tumor Targeting and Remodels Immunosuprressive Tumor Microenvironment
한국고분자학회 학술대회 연구논문 초록집
2021 .04
-
Amplification of transglutaminase 2 enhances tumor-promoting inflammation in gastric cancers
Experimental and Molecular Medicine
2020 .01
-
Clinical molecular subtyping reveals intrinsic mesenchymal reprogramming in gastric cancer cells
Experimental and Molecular Medicine
2023 .05
-
Metabolic influence on macrophage polarization and pathogenesis
BMB Reports
2019 .01
-
T Cell-mimicking Nanoparticles for Cancer Immunotherapy
한국고분자학회 학술대회 연구논문 초록집
2021 .04
-
Tumor microenvironment and radioresistance
Experimental and Molecular Medicine
2021 .06
-
The FBW7-MCL-1 axis is key in M1 and M2 macrophage-related colon cancer cell progression: validating the immunotherapeutic value of targeting PI3Kγ
Experimental and Molecular Medicine
2020 .01
-
플라즈마를 이용한 악취물질 분해 특성
한국산학기술학회 논문지
2020 .07
-
Antibody-secreting macrophages generated using CpG-free plasmid eliminate tumor cells through antibody-dependent cellular phagocytosis
BMB Reports
2020 .01
-
Single-cell RNA-Seq unveils tumor microenvironment
BMB Reports
2017 .06
-
Cancer immunotherapeutic strategy via organic-inorganic nanohybrids for priming tumor-associated macrophages toward anti-tumor phenotype
한국고분자학회 학술대회 연구논문 초록집
2018 .04
-
Alumina Oxide (Al₂O₃) Exacerbates the Inflammation by Activation of Macrophages and T Cells in the Mice in vivo
한국생물공학회 학술대회
2020 .06
-
Macrophage-Targeted, Adjustable Lipid Particles for Gene Therapy in Inflammatory Diseases
한국생물공학회 학술대회
2023 .10
-
3D Cell Printing of Stomach Cancer Model with Vasculature for Preclinical Assays by Providing a Tissue-specific Microenvironment
한국정밀공학회 학술발표대회 논문집
2021 .05
이 논문의 저자 정보
최근 본 자료
댓글(0)
0