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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 295 - 300 (6page)
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초록· 키워드
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Stress and its related hormones epinephrine (E) and norepinephrine (NE) play a crucial role in tumor progression.
Macrophages in the tumor microenvironment (TME) polarized to M2 is also a vital pathway for tumor deterioration. Here, we explore the underlying role of macrophages in the effect of stress and E promoting breast cancer growth. It was found that the weight and volume of tumor in tumor bearing mice were increased, and dramatically accompanied with the rising E level after chronic stress using social isolation. What is most noteworthy, the number of M2 macrophages inside tumor was up-regulated with it. The effects of E treatment appear to be directly related to the change of M2 phenotype is reproduced in vitro. Moreover, E receptor ADR2 involved in E promoting M2 polarization was comprehended simultaneously. Our results imply psychological stress is influential on specific immune system, more essential for the comprehensive treatment against tumors.
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등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
Ben-Eliyahu S / 2007 / Stress, NK cells, and cancer: Still a promissory note / Brain Behav Immun 21 : 881 ~ 887
Bingle L / 2002 / The role of tumour-associated macrophages in tumour progression: implications for new anticancer therapies / J Pathol 196 : 254 ~ 265
Bruzzone A / 2011 / alpha(2)-Adrenoceptors enhance cell proliferation and mammary tumor growth acting through both the stroma and the tumor cells / Curr Cancer Drug Targets
Deng GH / 2014 / Exogenous norepinephrine attenuates the efficacy of sunitinib in a mouse cancer model / J Exp Clin Cancer Res 33 : 21 ~
Du Y / 2012 / beta1-adrenergic receptor autoantibodies from heart failure patients enhanced TNF-alpha secretion in RAW264. 7 macrophages in a largely PKA-dependent fashion /
Bingle L / 2002 / The role of tumour-associated macrophages in tumour progression: implications for new anticancer therapies / J Pathol 196 : 254 ~ 265
Bruzzone A / 2011 / alpha(2)-Adrenoceptors enhance cell proliferation and mammary tumor growth acting through both the stroma and the tumor cells / Curr Cancer Drug Targets
Deng GH / 2014 / Exogenous norepinephrine attenuates the efficacy of sunitinib in a mouse cancer model / J Exp Clin Cancer Res 33 : 21 ~
Du Y / 2012 / beta1-adrenergic receptor autoantibodies from heart failure patients enhanced TNF-alpha secretion in RAW264. 7 macrophages in a largely PKA-dependent fashion /
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