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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 360 - 372 (13page)
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초록· 키워드
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Macrophages play an essential role not only in mediating the first line of defense but also in maintaining tissue homeostasis. In response to extrinsic factors derived from a given tissue, macrophages activate different functional programs to produce polarized macrophage populations responsible for inducing inflammation against microbes, removing cellular debris, and tissue repair. However, accumulating evidence has revealed that macrophage polarization is pivotal in the pathophysiology of metabolic syndromes and cancer, as well as in infectious and autoimmune diseases. Recent advances in transcriptomic and metabolomic studies have highlighted the link between metabolic rewiring of macrophages and their functional plasticity. These findings imply that metabolic adaption to their surrounding microenvironment instructs activation of macrophages with functionally distinct phenotypes, which in turn probably leads to the pathogenesis of a wide spectrum of diseases. In this review, we have introduced emerging concepts in immunometabolism with focus on the impact on functional activation of macrophages. Furthermore, we have discussed the implication of macrophage plasticity on the pathogenesis of metabolic syndromes and cancer, and how the disease microenvironment manipulates macrophage metabolism with regard to the pathophysiology.
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참고문헌 (142)
참고문헌 신청
Cohn ZA / 1965 / The Differentiation of Mononuclear Phagocytes. Morphology, Cytochemistry, and Biochemistry / J Exp Med 121:153~170
Rouzer CA / 1982 / Secretion of leukotriene C and other arachidonic acid metabolites by macrophages challenged with immunoglobulin E immune complexes / J Exp Med 156:1077~1086
Poltorak A / 1998 / Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice : mutations in Tlr4 gene / Science 282:2085~2088
Takeda K / 2003 / Toll-like receptors / Annu Rev Immunol 21:335~376
Medzhitov R / 1997 / A human homologue of the Drosophila Toll protein signals activation of adaptive immunity / Nature 388:394~397
Rouzer CA / 1982 / Secretion of leukotriene C and other arachidonic acid metabolites by macrophages challenged with immunoglobulin E immune complexes / J Exp Med 156:1077~1086
Poltorak A / 1998 / Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice : mutations in Tlr4 gene / Science 282:2085~2088
Takeda K / 2003 / Toll-like receptors / Annu Rev Immunol 21:335~376
Medzhitov R / 1997 / A human homologue of the Drosophila Toll protein signals activation of adaptive immunity / Nature 388:394~397
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