지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2023.2
- 수록면
- 457 - 469 (13page)
- DOI
- 10.1038/s12276-023-00946-w
이용수
초록· 키워드
오류제보하기
Liver metastasis is a major cause of death in gastric cancer patients, but the underlying mechanisms are poorly understood. Through a combination of in vivo screening and transcriptome profiling followed by quantitative RT-PCR and tissue array analyses, we found that mitogen-activated protein kinase 4 (MAPK4) downregulation in gastric cancer tissues from patients is significantly associated with liver metastasis and poor prognosis. The knockdown of MAPK4 in gastric cancer cells promotes liver metastasis in orthotopic mouse models. MAPK4 depletion in gastric cancer cells induces the secretion of macrophage migration inhibitory factor (MIF) to polarize tumor-associated macrophages (TAMs) in orthotopic xenograft tumors. Moreover, TAMs activate epithelial–mesenchymal transition of gastric cancer cells to suppress MAPK4 expression, which further increases MIF secretion to polarize TAMs. Taken together, our results suggest a previously undescribed positive feedback loop between cancer cells and macrophages mediated by MAPK4 silencing that facilitates gastric cancer liver metastasis.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Identification of gastric cancer biomarkers by comparison of the breath profiles of gastric cancer patients and healthy subjects
한국생물공학회 학술대회
2016 .10
-
The polyol pathway and nuclear ketohexokinase A signaling drive hyperglycemia-induced metastasis of gastric cancer
Experimental and Molecular Medicine
2024 .01
-
딥러닝 기반 위 질환 컴퓨터 보조 진단 시스템 개발 및 Grad-CAM을 활용한 시각화
전기학회논문지
2023 .02
-
Particulate matter promotes cancer metastasis through increased HBEGF expression in macrophages
Experimental and Molecular Medicine
2022 .11
-
Cholecystokinin as a Potent Diagnostic Marker for Gastric Cancer
BioChip Journal
2017 .01
-
Development of Isothermal Amplification-based Lateral Flow Biosensors for High-sensitive in vitro Diagnosis (IVD) of Gastric Cancer-associated MicroRNAs
한국생물공학회 학술대회
2021 .10
-
Tumor-promoting macrophages prevail in malignant ascites of advanced gastric cancer
Experimental and Molecular Medicine
2020 .12
-
Gastric Cancer Classification from histopathological images using patch based Radiomic Features and Advanced Machine Learning Techniques
한국정보통신학회 종합학술대회 논문집
2023 .10
-
특징 선택을 활용한 머신 러닝 기반의 위암 컴퓨터 보조 진단 시스템
전기학회논문지
2020 .01
-
ER membrane protein complex subunit 6 (EMC6) is a novel tumor suppressor in gastric cancer
BMB Reports
2017 .01
-
Helicobacter pylori-derived extracellular vesicles increased in the gastric juices of gastric adenocarcinoma patients and induced inflammation mainly via specific targeting of gastric epithelial cells
Experimental and Molecular Medicine
2017 .01
-
Characterization of metabolism in liver cancer stem cell using systems biologic methods
한국생물공학회 학술대회
2018 .10
-
Systematic Characterization of Liver Cancer Stem Cells
한국생물공학회 학술대회
2019 .10
-
T Cell-mimicking Nanoparticles for Cancer Immunotherapy
한국고분자학회 학술대회 연구논문 초록집
2021 .04
-
Cell heterogeneity and anisotropic movement are critical in cancer metastasis
한국고분자학회 학술대회 연구논문 초록집
2016 .10
-
Current Understanding of Stem Cell and Secretome Therapies in Liver Diseases
조직공학과 재생의학
2017 .01
-
위내시경 영상에서 위암 분류에 최적화된 데이터 증대방법 연구
전기학회논문지
2021 .12
-
Clinical implications of proliferation activity in T1 or T2 male gastric cancer patients
Experimental and Molecular Medicine
2015 .01
-
The FBW7-MCL-1 axis is key in M1 and M2 macrophage-related colon cancer cell progression: validating the immunotherapeutic value of targeting PI3Kγ
Experimental and Molecular Medicine
2020 .01
-
Screening of volatile organic compounds in breath of gastric cancer patients and healthy subjects which related to existence of tumor cells using SPME-GC/MS system
한국생물공학회 학술대회
2017 .10
이 논문의 저자 정보
최근 본 자료
댓글(0)
0