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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.6
- 수록면
- 506 - 514 (9page)
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The transcriptional regulation of genes determines the fate of animal cell differentiation and subsequent organ development. With the recent progress in genome-wide technologies, the genomic landscapes of enhancers have been broadly explored in mammalian genomes, which led to the discovery of novel specific subsets of enhancers, termed super-enhancers. Super-enhancers are large clusters of enhancers covering the long region of regulatory DNA and are densely occupied by transcription factors, active histone marks, and co-activators. Accumulating evidence points to the critical role that super-enhancers play in cell type-specific development and differentiation, as well as in the development of various diseases. Here, I provide a comprehensive description of the optimal approach for identifying functional units of super-enhancers and their unique chromatin features in normal development and in diseases, including cancers. I also review the recent updated knowledge on novel approaches of targeting super-enhancers for the treatment of specific diseases, such as small-molecule inhibitors and potential gene ther-apy. This review will provide perspectives on using super-enhancers as biomarkers to develop novel disease diagnostic tools and establish new directions in clinical therapeutic strategies.
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참고문헌 (61)
참고문헌 신청
Achour, M. / 2015 / Neuronal identity genes regulated by super-enhancers are preferentially down-regulated in the striatum of Huntington's disease mice / Hum. Mol. Genet. 24:3481~3496
Adam, R.C. / 2015 / Pioneer factors govern super-enhancer dynamics in stem cell plasticity and lineage choice / Nature 521:366~370
Amorim, S. / 2016 / Bromodomain inhibitor OTX015 in patients with lymphoma or multiple myeloma: a dose-escalation, open-label, pharmacokinetic, phase 1 study / Lancet Haematol. 3:e196~e204
Banerji, J. / 1981 / Expression of a beta-globin gene is enhanced by remote SV40 DNA sequences / Cell 27:299~308
Banerji, J. / 1983 / A lymphocyte-specific cellular enhancer is located downstream of the joining region in immunoglobulin heavy chain genes / Cell 33:729~740
Adam, R.C. / 2015 / Pioneer factors govern super-enhancer dynamics in stem cell plasticity and lineage choice / Nature 521:366~370
Amorim, S. / 2016 / Bromodomain inhibitor OTX015 in patients with lymphoma or multiple myeloma: a dose-escalation, open-label, pharmacokinetic, phase 1 study / Lancet Haematol. 3:e196~e204
Banerji, J. / 1981 / Expression of a beta-globin gene is enhanced by remote SV40 DNA sequences / Cell 27:299~308
Banerji, J. / 1983 / A lymphocyte-specific cellular enhancer is located downstream of the joining region in immunoglobulin heavy chain genes / Cell 33:729~740
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