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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.3
- 수록면
- 169 - 177 (9page)
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Tissue-specific transcription is critical for normal development, and abnormalities causing undesirable gene expression may lead to diseases such as cancer. Such highly organized transcription is controlled by enhancers with specific DNA sequences recognized by transcription factors. Enhancers are associated with chromatin modifications that are distinct epigenetic features in a tissue-specific manner. Recently, super-enhancers comprising enhancer clusters co-occupied by lineage-specific factors have been identified in diverse cell types such as adipocytes, hair follicle stem cells, and mammary epithelial cells. In addition, noncoding RNAs, named eRNAs, are synthesized at super-enhancer regions before their target genes are transcribed. Many functional studies revealed that super-enhancers and eRNAs are essential for the regulation of tissue-specific gene expression. In this review, we summarize recent findings concerning enhancer function in tissue-specific gene regulation and cancer development.
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참고문헌 (70)
참고문헌 신청
Adam, R. C. / 2015 / Pioneer factors govern super-enhancer dynamics in stem cell plasticity and lineage choice / Nature 521:366~370
Affer, M. / 2014 / Promiscuous MYC locus rearrangements hijack enhancers but mostly super-enhancers to dysregulate MYC expression in multiple myeloma / Leukemia 28:1725~1735
Andersson, R. / 2015 / Promoter or enhancer, what's the difference? Deconstruction of established distinctions and presentation of a unifying model / Bioessays 37:314~323
Andersson, R. / 2014 / An atlas of active enhancers across human cell types and tissues / Nature 507:455~461
Beagrie, R.A. / 2016 / Gene activation by metazoan enhancers: Diverse mechanisms stimulate distinct steps of transcription / Bioessays 38:881~893
Affer, M. / 2014 / Promiscuous MYC locus rearrangements hijack enhancers but mostly super-enhancers to dysregulate MYC expression in multiple myeloma / Leukemia 28:1725~1735
Andersson, R. / 2015 / Promoter or enhancer, what's the difference? Deconstruction of established distinctions and presentation of a unifying model / Bioessays 37:314~323
Andersson, R. / 2014 / An atlas of active enhancers across human cell types and tissues / Nature 507:455~461
Beagrie, R.A. / 2016 / Gene activation by metazoan enhancers: Diverse mechanisms stimulate distinct steps of transcription / Bioessays 38:881~893
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