지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 1,011 - 1,022 (12page)
이용수
초록· 키워드
오류제보하기
Cell type specification is a delicate biological event in which every step is under tight regulation. From a molecular point of view, cell fate commitment begins with chromatin alteration, which kickstarts lineage-determining factors to initiate a series of genes required for cell specification. Several important neuronal differentiation factors have been identified from ectopic over-expression studies. However, there is scarce information on which DNA regions are modified during induced pluripotent stem cell (iPSC) to neuronal progenitor cell (NPC) differentiation, the cis regulatory factors that attach to these accessible regions, or the genes that are initially expressed. In this study, we identified the DNA accessible regions of iPSCs and NPCs via the Assay for Transposase-Accessible Chromatin sequencing (ATACseq). We identified which chromatin regions were modified after neuronal differentiation and found that the enhancer regions had more active histone modification changes than the promoters. Through motif enrichment analysis, we found that NEUROD1 controls iPSC differentiation to NPC by binding to the accessible regions of enhancers in cooperation with other factors such as the Hox proteins. Finally, by using Hi-C data, we categorized the genes that directly interacted with the enhancers under the control of NEUROD1 during iPSC to NPC differentiation.
목차
등록된 정보가 없습니다.
참고문헌 (60)
참고문헌 신청
Akiyama, K. / 2008 / mRNA expression of activity-regulated cytoskeleton-associated protein(arc)in the amygdalakindled rats / Brain Res 1189:236~246
Baker, N. E. / 2018 / All in the family: proneural bHLH genes and neuronal diversity / Development 145:dev159426
Bel-Vialar, S. / 2007 / The on/off of Pax6controls the tempo of neuronal differentiation in the developing spinal cord / Dev. Biol 305:659~673
Bertrand, N. / 2002 / Proneural genes and the specification of neural cell types / Nat. Rev. Neurosci 3:517~530
Brunet, J. F. / 2002 / Phox2 genes-from patterning to connectivity / Curr. Opin. Genet. Dev 12:435~440
Baker, N. E. / 2018 / All in the family: proneural bHLH genes and neuronal diversity / Development 145:dev159426
Bel-Vialar, S. / 2007 / The on/off of Pax6controls the tempo of neuronal differentiation in the developing spinal cord / Dev. Biol 305:659~673
Bertrand, N. / 2002 / Proneural genes and the specification of neural cell types / Nat. Rev. Neurosci 3:517~530
Brunet, J. F. / 2002 / Phox2 genes-from patterning to connectivity / Curr. Opin. Genet. Dev 12:435~440
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
iPSC-Derived Natural Killer Cells for Cancer Immunotherapy
Molecules and Cells
2021 .08
-
Directed Differentiation of Pluripotent Stem Cells by Trascription Factors
Molecules and Cells
2019 .01
-
ROCK 억제제를 통한 사람 치유두 조직 유래 단일 사람 유도만능줄기세포의 생존성 향상
생명과학회지
2019 .08
-
The Role of Stress Granules in the Neuronal Differentiation of Stem Cells
Molecules and Cells
2020 .01
-
Homeostatic balance of histone acetylation and deconstruction of repressive chromatin marker H3K9me3 during adipocyte differentiation of 3T3-L1 cells
Genes & Genomics
2018 .01
-
Targeting Super-Enhancers for Disease Treatment and Diagnosis
Molecules and Cells
2018 .06
-
Functional Enhancers As Master Regulators of Tissue-Specific Gene Regulation and Cancer Development
Molecules and Cells
2017 .03
-
A concise guide to essential R packages for analyses of DNA, RNA, and proteins
Molecules and Cells
2024 .01
-
The RUNX1 Enhancer Element eR1: A Versatile Marker for Adult Stem Cells
Molecules and Cells
2020 .01
-
Epigenetic Regulations in Mammalian Cells: Roles and Profiling Techniques
Molecules and Cells
2023 .02
-
Homogeneity of XEN Cells Is Critical for Generation of Chemically Induced Pluripotent Stem Cells
Molecules and Cells
2023 .04
-
Characterization of Structural Variations in the Context of 3D Chromatin Structure
Molecules and Cells
2019 .01
-
Differentiation of mesenchymal stem cells on nanopillar/pit array structures
한국진공학회 학술발표회초록집
2017 .02
-
Genetic Architecture of Transcription and Chromatin Regulation
Genomics & informatics
2015 .01
-
Reversine과 세포의 역분화 및 교차분화
생명과학회지
2020 .04
-
HiCORE: Hi-C Analysis for Identification of Core Chromatin Looping Regions with Higher Resolution
Molecules and Cells
2021 .12
-
Post-Translational Modifications in Transcription Factors that Determine T Helper Cell Differentiation
Molecules and Cells
2021 .01
-
The Chromatin Accessibility Landscape of Nonalcoholic Fatty Liver Disease Progression
Molecules and Cells
2022 .05
-
Visualizing Live Chromatin Dynamics through CRISPR-Based Imaging Techniques
Molecules and Cells
2021 .09
-
MicroRNA-126은 난소 종양세포의 줄기세포 전사인자 (Sox2와 Lin28) 발현을 조절한다
대한임상검사과학회지
2015 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0