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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.9
- 수록면
- 658 - 669 (12page)
- DOI
- 10.14348/molcells.2021.0173
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초록· 키워드
오류제보하기
Enhancers have been conventionally perceived as cis-acting elements that provide binding sites for trans-acting factors. However, recent studies have shown that enhancers are transcribed and that these transcripts, called enhancer RNAs (eRNAs), have a regulatory function. Here, we identified putative eRNAs by profiling and determining the overlap between noncoding RNA expression loci and eRNA-associated histone marks such as H3K27ac and H3K4me1 in hepatocellular carcinoma (HCC) cell lines. Of the 132 HCC-derived noncoding RNAs, 74 overlapped with the eRNA loci defined by the FANTOM consortium, and 65 were located in the proximal regions of genes differentially expressed between normal and tumor tissues in TCGA dataset. Interestingly, knockdown of two selected putative eRNAs, THUMPD3-AS1 and LINC01572, led to downregulation of their target mRNAs and to a reduction in the proliferation and migration of HCC cells. Additionally, the expression of these two noncoding RNAs and target mRNAs was elevated in tumor samples in the TCGA dataset, and high expression was associated with poor survival of patients. Collectively, our study suggests that noncoding RNAs such as THUMPD3-AS1 and LINC01572 (i.e., putative eRNAs) can promote the transcription of genes involved in cell proliferation and differentiation and that the dysregulation of these noncoding RNAs can cause cancers such as HCC.
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참고문헌 (55)
참고문헌 신청
Alexander, J. J. / 1976 / Establishment of a continuously growing cell line from primary carcinoma of the liver / S. Afr. Med. J. 50:2124~2128
Ali, T. / 2020 / Beyond the RNA-dependent function of LncRNA genes / Elife 9:e60583
Alvarez-Dominguez, J. R. / 2017 / The super-enhancer-derived alncRNA-EC7/Bloodlinc potentiates red blood cell development in trans / Cell Rep 19:2503~2514
Anders, S. / 2015 / HTSeq—a Python framework to work with high-throughput sequencing data / Bioinformatics 31:166~169
Andersson, R. / 2014 / An atlas of active enhancers across human cell types and tissues / Nature 507:455~461
Ali, T. / 2020 / Beyond the RNA-dependent function of LncRNA genes / Elife 9:e60583
Alvarez-Dominguez, J. R. / 2017 / The super-enhancer-derived alncRNA-EC7/Bloodlinc potentiates red blood cell development in trans / Cell Rep 19:2503~2514
Anders, S. / 2015 / HTSeq—a Python framework to work with high-throughput sequencing data / Bioinformatics 31:166~169
Andersson, R. / 2014 / An atlas of active enhancers across human cell types and tissues / Nature 507:455~461
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