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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.2
- 수록면
- 93 - 102 (10page)
- DOI
- 10.14348/molcells.2018.2163
이용수
초록· 키워드
오류제보하기
Discoidin domain receptor 1 (DDR1) is involved in tumor-igenesis and angiogenesis. However, its role in lymphangiogenesis has been unknown. Here, we tested whether downregulation of DDR1 expression by miR-199a/b can suppress lymphangiogenesis. We also aimed to identify miRNA target site(s) in the 3? untranslated region (UTR) of DDR1. Transfection with miR-199a/b-5p mimics reduced expression of DDR1 and tube formation in primary human dermal lymphatic endothelial cells, whereas miR-199a/b-5p inhibitors showed the opposite effects. Critically, injection of miR-199a/b-5p mimics suppressed DDR1 expression and lymphangiogenesis in a corneal alkali-burn rat model. The three well-conserved seed matched sites for miR-199a/b-5p in the DDR1 3?-UTR were targeted, and miRNA binding to at least two sites was required for DDR1 inhibition. Our data suggest that DDR1 promotes enhanced lymphangiogenesis during eye injury, and miR-199a/b-5p suppresses this activity by inhibiting DDR1 expression. Thus, this miRNA may be useful for the treatment of lymphangiogenesis-related eye diseases.
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등록된 정보가 없습니다.
참고문헌 (42)
참고문헌 신청
Arnaoutova, I. / 2009 / The endothelial cell tube formation assay on basement membrane turns 20: state of the science and the art / Angiogenesis 12:267~274
Bachmann, B. / 2008 / Promotion of graft survival by vascular endothelial growth factor a neutralization after high-risk corneal transplantation / Arch. Ophthalmol. 126:71~77
Bartel, D.P / 2009 / MicroRNAs: target recognition and regulatory functions / Cell 136:215~233
Borza, C.M. / 2014 / Discoidin domain receptors in disease / Matrix Biol. 34:185~192
Breiteneder-Geleff, S. / 1999 / Angiosarcomas express mixed endothelial phenotypes of blood and lymphatic capillaries: podoplanin as a specific marker for lymphatic endothelium / Am. J. Pathol. 154:154
Bachmann, B. / 2008 / Promotion of graft survival by vascular endothelial growth factor a neutralization after high-risk corneal transplantation / Arch. Ophthalmol. 126:71~77
Bartel, D.P / 2009 / MicroRNAs: target recognition and regulatory functions / Cell 136:215~233
Borza, C.M. / 2014 / Discoidin domain receptors in disease / Matrix Biol. 34:185~192
Breiteneder-Geleff, S. / 1999 / Angiosarcomas express mixed endothelial phenotypes of blood and lymphatic capillaries: podoplanin as a specific marker for lymphatic endothelium / Am. J. Pathol. 154:154
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