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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 65 - 72 (8page)
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Autophagy is an evolutionally conserved cytoplasmic degradation system in which varieties of materials are sequestered by a double membrane structure, autophagosome, and delivered to the lysosomes for the degradation. Due to the wide varieties of targets, autophagic activity is essential for cellular homeostasis. Recent genetic evidence indicates that autophagy has a crucial role in the regulation of animal lifespan. Basal level of autophagic activity is elevated in many longevity paradigms and the activity is required for lifespan extension. In most cases, genes involved in autophagy and lysosomal function are induced by several transcription factors including HLH-30/TFEB, PHA-4/FOXA and MML-1/Mondo in long-lived animals. Pharmacological treatments have been shown to extend lifespan through activation of autophagy, indicating autophagy could be a potential and promising target to modulate animal lifespan. Here we summarize recent progress regarding the role of autophagy in lifespan regulation.
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참고문헌 (65)
참고문헌 신청
Alvers, A.L. / 2009 / Autophagy and amino acid homeostasis are required for chronological longevity in Saccharomyces cerevisiae / Aging Cell 8:353~369
Alvers, A.L. / 2009 / Autophagy is required for extension of yeast chronological life span by rapamycin / Autophagy 5:847~849
Apfeld, J. / 2004 / The AMP-activated protein kinase AAK-2 links energy levels and insulin-like signals to lifespan in C. elegans / Genes Dev 18:3004~3009
Bjedov, I. / 2010 / Mechanisms of life span extension by rapamycin in the fruit fly Drosophila melanogaster / Cell Metab 11:35~46
Chan, S.N. / 2013 / Location and membrane sources for autophagosome formation - from ER-mitochondria contact sites to Golgi-endosome-derived carriers / Mol. Membr. Biol. 30:394~402
Alvers, A.L. / 2009 / Autophagy is required for extension of yeast chronological life span by rapamycin / Autophagy 5:847~849
Apfeld, J. / 2004 / The AMP-activated protein kinase AAK-2 links energy levels and insulin-like signals to lifespan in C. elegans / Genes Dev 18:3004~3009
Bjedov, I. / 2010 / Mechanisms of life span extension by rapamycin in the fruit fly Drosophila melanogaster / Cell Metab 11:35~46
Chan, S.N. / 2013 / Location and membrane sources for autophagosome formation - from ER-mitochondria contact sites to Golgi-endosome-derived carriers / Mol. Membr. Biol. 30:394~402
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