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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 221 - 234 (14page)
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Cancer is genetically, metabolically and infectiously induced life threatening disorder showing aggressive growing pattern with invasive tendency. In order to prevent this global menace from jeopardizing human life, enormous studies on carcinogenesis and treatment for chemotherapy resistance have been intensively researched. Hinokitiol (β-thujaplicin) extracted from heart wood of cupressaceous is a well-known bioactive compound demonstrating anti-inflammation, anti-bacteria and anti-cancer effects on several cancer types via apoptosis and autophagy. This study proposed that hinokitiol activates transcription factor EB (TFEB) nuclear translocation for autophagy and lysosomal biogenesis regardless of nutrient condition in cancer cells. Mitophagy and β-catenin translocation into the nucleus under treatment of hinokitiol on non-small cell lung cancer (NSCLC) cells and HeLa cells were investigated. Hinokitiol exerted cytotoxicity on HeLa and HCC827 cells; moreover, artificially induced autophagy by overexpression of TFEB granted imperfect sustainability onto HeLa cells. Taken together, hinokitiol is the prominent autophagy inducer and activator of TFEB nuclear translocation. Alternative cancer therapy via autophagy is pros and cons since the autophagy in cancer cells is related to prevention and survival mechanism depending on nutrition. To avoid paradox of autophagy in cancer therapy, fine-tuned regulation and application of hinokitiol in due course for successful suppressing cancer cells are recommended.
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참고문헌 (39)
참고문헌 신청
Wei-Kuang Wang / 2016 / Hinokitiol induces autophagy in murine breast and colorectal cancer cells / Environmental Toxicology 31(1):77~84
Saniewski M / 2014 / The biological activities of troponoids and their use in agriculture a review / J Hortic Res 22:5~19
Glick D / 2010 / Autophagy : cellular and molecular mechanisms / J Pathol 221:3~12
Mizushima N / 2011 / Autophagy : renovation of cells and tissues / Cell 147:728~741
Mizushima N / 2007 / Autophagy : process and function / Genes Dev 21:2861~2873
Saniewski M / 2014 / The biological activities of troponoids and their use in agriculture a review / J Hortic Res 22:5~19
Glick D / 2010 / Autophagy : cellular and molecular mechanisms / J Pathol 221:3~12
Mizushima N / 2011 / Autophagy : renovation of cells and tissues / Cell 147:728~741
Mizushima N / 2007 / Autophagy : process and function / Genes Dev 21:2861~2873
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