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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.11
- 수록면
- 880 - 887 (8page)
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We hypothesized that inflammation affects number and activity of osteoclasts (OCs) via enhancing autophagy. Lipopolysaccharide (LPS) induced autophagy, osteoclastogenesis, and cytoplasmic reactive oxygen species (ROS) in bone marrow-derived macrophages that were pre-stimulated with receptor activator of nuclear factor-κB ligand. An autophagy inhibitor, 3-methyladenine (3-MA) decreased LPS-induced OC formation and bone resorption, indicating that autophagy is responsible for increasing number and activity of OCs upon LPS stimulus. Knockdown of autophagy-related protein 7 attenuated the effect of LPS on OC-specific genes, supporting a role of LPS as an autophagy inducer in OC. Removal of ROS decreased LPS-induced OC formation as well as autophagy. However, 3-MA did not affect LPS-induced ROS levels, suggesting that ROS act upstream of phosphatidylinositol-4,5-bisphosphate 3-kinase in LPS-induced autophagy. Our results suggest the possible use of autophagy inhibitors targeting OCs to reduce inflammatory bone loss.
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등록된 정보가 없습니다.
참고문헌 (29)
참고문헌 신청
Budanov, A. V. / 2008 / p53 target genes sestrin1 and sestrin2 connect genotoxic stress and mTOR signaling / Cell 134:451~460
Cejka, D. / 2010 / Mammalian target of rapamycin signaling is crucial for joint destruction in experimental arthritis and is activated in osteoclasts from patients with rheumatoid arthritis / Arthritis Rheum 62:2294~2302
Chamoux, E. / 2009 / The p62 P392L mutation linked to Paget's disease induces activation of human osteoclasts / Mol. Endocrinol 23:1668~1680
Chang, N. C. / 2010 / Antagonism of Beclin 1-dependent autophagy by BCL-2 at the endoplasmic reticulum requires NAF-1 / EMBO J 29:606~618
Chen, Y. / 2007 / Mitochondrial electron-transport-chain inhibitors of complexes I and II induce autophagic cell death mediated by reactive oxygen species / J. Cell Sci 120:4155~4166
Cejka, D. / 2010 / Mammalian target of rapamycin signaling is crucial for joint destruction in experimental arthritis and is activated in osteoclasts from patients with rheumatoid arthritis / Arthritis Rheum 62:2294~2302
Chamoux, E. / 2009 / The p62 P392L mutation linked to Paget's disease induces activation of human osteoclasts / Mol. Endocrinol 23:1668~1680
Chang, N. C. / 2010 / Antagonism of Beclin 1-dependent autophagy by BCL-2 at the endoplasmic reticulum requires NAF-1 / EMBO J 29:606~618
Chen, Y. / 2007 / Mitochondrial electron-transport-chain inhibitors of complexes I and II induce autophagic cell death mediated by reactive oxygen species / J. Cell Sci 120:4155~4166
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