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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 3 - 10 (8page)
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Autophagy is one of the major degradative mechanisms that can eliminate excessive nutrients, toxic protein aggregates, damaged organelles and invading microorganisms. In re-sponse to obesity and obesity-associated lipotoxic, proteotoxic and oxidative stresses, autophagy plays an essential role in maintaining physiological homeostasis. However, obesity and its associated stress insults can often interfere with the autophagic process through various mechanisms, which result in further aggravation of obesity-related metabolic pathologies in multiple metabolic organs. Paradoxically, inhibition of autophagy, within specific contexts, indirectly produces beneficial effects that can alleviate several detrimental consequences of obesity. In this minireview, we will provide a brief discussion about our current understanding of the impact of obesity on autophagy and the role of autophagy dysregula-tion in modulating obesity-associated pathological outcomes.
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참고문헌 (113)
참고문헌 신청
Alers, S. / 2012 / The incredible ULKs / Cell Commun. Signal. 10:7
Alers, S. / 2012 / Role of AMPK-mTOR-Ulk1/2 in the regulation of autophagy: cross talk, shortcuts, and feedbacks / Mol. Cell Biol. 32:2~11
Arruda, A.P. / 2015 / Calcium homeostasis and organelle function in the pathogenesis of obesity and diabetes / Cell Metab. 22:381~397
Bartolome, A. / 2012 / Autophagy plays a protective role in endoplasmic reticulum stress-mediated pancreatic beta cell death / Autophagy 8:1757~1768
Basseri, S. / 2008 / ER stress and lipogenesis: a slippery slope toward hepatic steatosis / Dev. Cell 15:795~796
Alers, S. / 2012 / Role of AMPK-mTOR-Ulk1/2 in the regulation of autophagy: cross talk, shortcuts, and feedbacks / Mol. Cell Biol. 32:2~11
Arruda, A.P. / 2015 / Calcium homeostasis and organelle function in the pathogenesis of obesity and diabetes / Cell Metab. 22:381~397
Bartolome, A. / 2012 / Autophagy plays a protective role in endoplasmic reticulum stress-mediated pancreatic beta cell death / Autophagy 8:1757~1768
Basseri, S. / 2008 / ER stress and lipogenesis: a slippery slope toward hepatic steatosis / Dev. Cell 15:795~796
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