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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.12
- 수록면
- 945 - 953 (9page)
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We report the biological functions of a zebrafish homologue of RING-finger protein 152 (rnf152) during embryogenesis. rnf152 was initially iden-tified as a brain-enriched E3 ligase involved in early embryogenesis of zebrafish. Expression of rnf152 was ubiquitous in the brain at 24 hpf but restricted to the eyes, midbrain-hindbrain boundary (MHB), and rhombomeres at 48 hpf. Knockdown of rnf152 in zebrafish embryos caused defects in the eyes, MHB, and rhombomeres (r1?7) at 24 hpf. These defects in rnf152-deficient embryos were analyzed by whole-mount in situ hybridization (WISH) using neuroD, deltaD, notch1a, and notch3 probes. NeuroD expression was abolished in the marginal zone, outer nuclear layer (ONL), inner nuclear layer (INL), and ganglion cell layer (GCL) of the eyes at 27 hpf. Furthermore, deltaD and notch1a expression was remarkably reduced in the ONL, INL, subpallium, tectum, cerebellum, and rhombomeres (r1-7) at 24 hpf, whereas notch3 expression was reduced in the tectum, cerebellum, and rhombomeres at 24 hpf. Finally, we confirmed that expression of Notch target genes, her4 and ascl1a, also decreased significantly in these areas at 24 hpf. Thus, we propose that Rnf152 is essential for development of the eyes, midbrain and hindbrain, and that Delta-Notch signaling is involved.
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참고문헌 (34)
참고문헌 신청
Mrudhula Anuppalle / 2013 / Ubiquitin proteasome system networks in the neurological disorders / Animal Cells and Systems 17(6):383~387
Anuppalle, M. / 2017 / Notch and retinoic acid signaling are required for the spatiotemporal distribution of prune2 mRNA in the zebrafish embryonic development / Gene Exp. Patterns 11(23-24):45~51
Banote, R. K. / 2016 / β-Amyloid precursor protein-b is essential for Mauthner cell development in the zebrafish in a Notchdependent manner / Dev. Biol 413:26~38
Chen, W. B. / 2004 / Three modules of zebrafish Mind bomb work cooperatively to promote Delta ubiquitination and endocytosis / Dev. Biol 267:361~373
Deng, L. / 2015 / The ubiquitination of RagA GTPase by RNF152 negatively regulates mTORC1 activation / Mol. Cell 58:804~818
Anuppalle, M. / 2017 / Notch and retinoic acid signaling are required for the spatiotemporal distribution of prune2 mRNA in the zebrafish embryonic development / Gene Exp. Patterns 11(23-24):45~51
Banote, R. K. / 2016 / β-Amyloid precursor protein-b is essential for Mauthner cell development in the zebrafish in a Notchdependent manner / Dev. Biol 413:26~38
Chen, W. B. / 2004 / Three modules of zebrafish Mind bomb work cooperatively to promote Delta ubiquitination and endocytosis / Dev. Biol 267:361~373
Deng, L. / 2015 / The ubiquitination of RagA GTPase by RNF152 negatively regulates mTORC1 activation / Mol. Cell 58:804~818
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