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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 76 - 85 (10page)
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MARCH5 is a RING finger E3 ligase involved in mitochondrial integrity, cellular protein homeostasis, and the regulation of mitochondrial fusion and fission. To determine the function of MARCH5 during development, we assessed transcript expression in zebrafish embryos. We found that march5 transcripts were of maternal origin and evenly distributed at the 1-cell stage, except for the mid-blastula transition, with expression predominantly in the developing central nervous system at later stages of embryogenesis. Overexpression of march5 impaired convergent extension movement during gastrulation, resulting in reduced patterning along the dorsoventral axis and alterations in the ventral cell types. Overexpression and knockdown of march5 disrupted the organization of the developing telencephalon and diencephalon. Lastly, we found that the transcription of march5 was tightly regulated by the transcriptional regulators CHOP, C/EBPα, Staf, Znf143a, and Znf76. These results demonstrate the essential role of March5 in the development of zebrafish embryos.
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참고문헌 (58)
참고문헌 신청
Barth, K. A. / 1999 / Bmp activity establishes a gradient of positional information throughout the entire neural plate / Development 126:4977~4987
Carlson, B. A. / 2009 / The selenocysteine tRNA STAF-binding region is essential for adequate selenocysteine tRNA status, selenoprotein expression and early age survival of mice / Biochem. J 418:61~71
Chen, H. / 2003 / Mitofusins Mfn1 and Mfn2 coordinately regulate mitochondrial fusion and are essential for embryonic development / J. Cell Biol 160:189~200
Cherok, E. / 2017 / Novel regulatory roles of Mff and Drp1 in E3ubiquitin ligase MARCH5–dependent degradation of MiD49 and Mcl1and control of mitochondrial dynamics / Mol. Biol. Cell 28:396~410
Chuang, J. C. / 1999 / Expression of three Rx homeobox genes in embryonic and adult zebrafish / Mech. Dev 84:195~198
Carlson, B. A. / 2009 / The selenocysteine tRNA STAF-binding region is essential for adequate selenocysteine tRNA status, selenoprotein expression and early age survival of mice / Biochem. J 418:61~71
Chen, H. / 2003 / Mitofusins Mfn1 and Mfn2 coordinately regulate mitochondrial fusion and are essential for embryonic development / J. Cell Biol 160:189~200
Cherok, E. / 2017 / Novel regulatory roles of Mff and Drp1 in E3ubiquitin ligase MARCH5–dependent degradation of MiD49 and Mcl1and control of mitochondrial dynamics / Mol. Biol. Cell 28:396~410
Chuang, J. C. / 1999 / Expression of three Rx homeobox genes in embryonic and adult zebrafish / Mech. Dev 84:195~198
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