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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.8
- 수록면
- 550 - 557 (8page)
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The periodontal ligament (PDL) is the connective tissue between tooth root and alveolar bone containing mesenchymal stem cells (MSC). It has been suggested that human periodontal ligament stem cells (hPDLSCs) differentiate into osteo/cementoblast and ligament progenitor cells. The periodontitis is a representative oral disease where the PDL tissue is collapsed, and regeneration of this tissue is important in periodontitis therapy. Fibroblast growth factor-2 (FGF-2) stimulates proliferation and differentiation of fibroblastic MSCs into various cell lineages. We evaluated the dose efficacy of FGF-2 for cytodifferentiation of hPDLSCs into ligament progenitor. The fibrous morphology was highly stimulated even at low FGF-2 concentrations, and the expression of teno/ ligamentogenic markers, scleraxis and tenomodulin in hPDLSCs increased in a dose dependent manner of FGF-2. In contrast, expression of the os-teo/cementogenic markers decreased, suggesting that FGF-2 might induce and maintain the ligamentogenic potential of hPDLSCs. Although the stimulation of tenocytic maturation by TGF-β1 was diminished by FGF-2, the inhibition of the expression of early ligamentogenic marker by TGF-β1 was redeemed by FGF-2 treatment. The stimulating effect of BMPs on osteo/cementogenesis was apparently suppressed by FGF-2. These results indicate that FGF-2 predominantly differentiates the hPDLSCs into teno/ligamentogenesis, and has an antagonistic effect on the hard tissue differentiation induced by BMP-2 and BMP-4.
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참고문헌 (29)
참고문헌 신청
Asano, M. / 2005 / Effect of connective tissue growth factor (CCN2/CTGF) on proliferation and differentiation of mouse periodontal ligament-derived cells / Cell Commun. Signal 3:11
Beertsen, W. / 1997 / The periodontal ligament: a unique, multifunctional connective tissue / Periodontology 2000 13:20~40
Bradfute, S. B. / 2005 / Roles of Sca-1 in hematopoietic stem/progenitor cell function / Exp. Hematol 33:836~843
Choi, J. K. / 2015 / The efficiency of the in vitro osteo/dentinogenic differentiation of human dental pulp cells, periodontal ligament cells and gingival fibroblasts / Int. J. Mol. Med 35:161~168
Dangaria, S. J. / 2009 / Extracellular matrix-mediated differentiation of periodontal progenitor cells / Differentiation 78:79~90
Beertsen, W. / 1997 / The periodontal ligament: a unique, multifunctional connective tissue / Periodontology 2000 13:20~40
Bradfute, S. B. / 2005 / Roles of Sca-1 in hematopoietic stem/progenitor cell function / Exp. Hematol 33:836~843
Choi, J. K. / 2015 / The efficiency of the in vitro osteo/dentinogenic differentiation of human dental pulp cells, periodontal ligament cells and gingival fibroblasts / Int. J. Mol. Med 35:161~168
Dangaria, S. J. / 2009 / Extracellular matrix-mediated differentiation of periodontal progenitor cells / Differentiation 78:79~90
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