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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.6
- 수록면
- 386 - 392 (7page)
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초록· 키워드
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Periodontal ligament stem cells (PDLSCs) are multipotent stem cells derived from periodontium and have mesenchymal stem cell (MSC)-like characteristics. Recently, the perivascular region was recognized as the developmental origin of MSCs, which suggests the in vivo angiogenic potential of PDLSCs. In this study, we investigated whether PDLSCs could be a potential source of perivascular cells, which could contribute to in vivo angiogenesis. PDLSCs exhibited typical MSC-like charac-teristics such as the expression pattern of surface markers (CD29, CD44, CD73, and CD105) and differentiation potentials (osteogenic and adipogenic differentiation). Moreover, PDLSCs expressed perivascular cell markers such as NG2, α-smooth muscle actin, platelet-derived growth factor receptor β, and CD146. We conducted an in vivo Matrigel plug assay to confirm the in vivo angiogenic potential of PDLSCs. We could not observe significant vessel-like structures with PDLSCs alone or human umbilical vein endothelial cells (HUVECs) alone at day 7 after injection. However, when PDLSCs and HUVECs were co-injected, there were vessel-like structures containing red blood cells in the lumens, which suggested that anastomosis occurred between newly formed vessels and host circulatory system. To block the SDF-1α and CXCR4 axis between PDLSCs and HUVECs, AMD3100, a CXCR4 antagonist, was added into the Matrigel plug. After day 3 and day 7 after injection, there were no significant vessel-like structures. In conclusion, we demonstrated the perivascular characteristics of PDLSCs and their contribution to in vivo angiogenesis, which might imply potential application of PDLSCs into the neovascularization of tissue engineering and vascular dis-eases.
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참고문헌 (37)
참고문헌 신청
Aiuti, A. / 1997 / The chemokine SDF-1 is a chemoattractant for human CD34+ hematopoietic progenitor cells and provides a new mechanism to explain the mobilization of CD34+ progenitors to peripheral blood / J. Exp. Med 185:111~120
Armulik, A. / 2005 / Endothelial/pericyte interactions / Circ. Res 97:512~523
Au, P. / 2008 / Differential in vivo potential of endothelial progenitor cells from human umbilical cord blood and adult peripheral blood to form functional long-lasting vessels / Blood 111:1302~1305
Chen, F. M. / 2010 / Periodontal tissue engineering and regeneration: current approaches and expanding opportunities / Tissue Eng. Part B Rev 16:219~255
Corselli, M. / 2010 / Perivascular ancestors of adult multipotent stem cells / Arterioscler. Thromb. Vasc. Biol 30:1104~1109
Armulik, A. / 2005 / Endothelial/pericyte interactions / Circ. Res 97:512~523
Au, P. / 2008 / Differential in vivo potential of endothelial progenitor cells from human umbilical cord blood and adult peripheral blood to form functional long-lasting vessels / Blood 111:1302~1305
Chen, F. M. / 2010 / Periodontal tissue engineering and regeneration: current approaches and expanding opportunities / Tissue Eng. Part B Rev 16:219~255
Corselli, M. / 2010 / Perivascular ancestors of adult multipotent stem cells / Arterioscler. Thromb. Vasc. Biol 30:1104~1109
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