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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 1,002 - 1,010 (9page)
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Cilia are important eukaryotic cellular compartments required for diverse biological functions. Recent studies have revealed that protein targeting into the proper ciliary subcompartments is essential for ciliary function. In Drosophila chordotonal cilium, where mechano-electric transduction occurs, two transient receptor potential (TRP) superfamily ion channels, TRPV and TRPN, are restricted to the proximal and distal subcompartments, respectively. To understand the mechanisms underlying the sub-ciliary segregation of the two TRPs, we analyzed their localization under various conditions. In developing chordotonal cilia, TRPN was directly targeted to the ciliary tip from the beginning of its appearance and was retained in the distal subcompartment throughout development, whereas the ciliary localization of TRPV was considerably delayed. Lack of intraflagella transport-related proteins affected TRPV from the initial stage of its pre-ciliary trafficking, whereas it affected TRPN from the ciliary entry stage. The ectopic expression of the two TRP channels in both ciliated and nonciliated cells revealed their intrinsic properties related to their localization. Taken together, our results suggest that subciliary segregation of the two TRP channels relies on their distinct intrinsic properties, and begins at the initial stage of their pre-ciliary trafficking.
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참고문헌 (25)
참고문헌 신청
Chung, Y. D. / 2001 / nompA encodes a PNS-specific, ZP domain protein required to connect mechanosensory dendrites to sensory structures / Neuron 29:415~428
Eberl, D. F. / 2000 / Genetically similar transduction mechanisms for touch and hearing in Drosophila / J. Neurosci 20:5981~5988
Follit, J. A. / 2006 / The intraflagellar transport protein IFT20 is associated with the Golgi complex and is required for cilia assembly / Mol. Biol. Cell 17:3781~3792
Gong, Z. / 2004 / Two interdependent TRPV channel subunits, Inactive and Nanchung, mediate hearing in Drosophila / J. Neurosci 24:9059~9066
Gopfert, M. C. / 2006 / Specification of auditory sensitivity by Drosophila TRP channels / Nat. Neurosci 9:999~1000
Eberl, D. F. / 2000 / Genetically similar transduction mechanisms for touch and hearing in Drosophila / J. Neurosci 20:5981~5988
Follit, J. A. / 2006 / The intraflagellar transport protein IFT20 is associated with the Golgi complex and is required for cilia assembly / Mol. Biol. Cell 17:3781~3792
Gong, Z. / 2004 / Two interdependent TRPV channel subunits, Inactive and Nanchung, mediate hearing in Drosophila / J. Neurosci 24:9059~9066
Gopfert, M. C. / 2006 / Specification of auditory sensitivity by Drosophila TRP channels / Nat. Neurosci 9:999~1000
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