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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제26권 제4호
- 발행연도
- 2016.1
- 수록면
- 693 - 699 (7page)
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초록· 키워드
오류제보하기
Clostridium difficile toxin A is known to cause deacetylation of tubulin proteins, which blocks microtubule formation and triggers barrier dysfunction in the gut. Based on our previous finding that the Clostridium difficile toxin A-dependent activation of histone deacetylase 6 (HDAC-6) is responsible for tubulin deacetylation and subsequent microtubule disassembly, we herein examined the possible effect of potassium acetate (PA; whose acetyl group prevents the binding of tubulin to HDAC-6) as a competitive/false substrate. Our results revealed that PA inhibited toxin A-induced deacetylation of tubulin and recovered toxin A-induced microtubule disassembly. In addition, PA treatment significantly decreased the production of IL-6 (a marker of inflamed tissue) in the toxin A-induced mouse enteritis model. An in vitro HDAC assay revealed that PA directly inhibited HDAC-6-mediated tubulin deacetylation, indicating that PA acted as a false substrate for HDAC-6. These results collectively indicate that PA treatment inhibits HDAC-6, thereby reducing the cytotoxicity and inflammatory responses caused by C. difficile toxin A.
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참고문헌 (28)
참고문헌 신청
Arregui L / 2002 / Direct visualization of the microtubular cytoskeleton of ciliated protozoa with a fluorescent taxoid / J. Eukaryot. Microbiol 49:312~318
Dhanya K / 2007 / Isolation and amplification of genomic DNA from recalcitrant dried berries of black pepper (Piper nigrum L.) - a medicinal spice / Mol. Biotechnol 37:165~168
Donet JA / 2015 / Acute respiratory distress syndrome due to Clostridium difficile colitis: a case report and rev iew of the literature / Rev. Gastroenterol. Peru 35:262~264
Dupre-Aucouturier S / 1985 / Trichostatin A, a histone deacetylase inhibitor, modulates unloaded-induced skeletal muscle atrophy / J. Appl. Physiol 119:342~351
Hato Z / 2014 / Water-mediated potassium acetate intercalation in kaolinite as revealed by molecular simulation / J. Mol. Model 20:2140
Dhanya K / 2007 / Isolation and amplification of genomic DNA from recalcitrant dried berries of black pepper (Piper nigrum L.) - a medicinal spice / Mol. Biotechnol 37:165~168
Donet JA / 2015 / Acute respiratory distress syndrome due to Clostridium difficile colitis: a case report and rev iew of the literature / Rev. Gastroenterol. Peru 35:262~264
Dupre-Aucouturier S / 1985 / Trichostatin A, a histone deacetylase inhibitor, modulates unloaded-induced skeletal muscle atrophy / J. Appl. Physiol 119:342~351
Hato Z / 2014 / Water-mediated potassium acetate intercalation in kaolinite as revealed by molecular simulation / J. Mol. Model 20:2140
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