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논문 기본 정보

자료유형
학술저널
저자정보
Jaeho Kim (Department of Radiology Brigham and Women’s Hospital Harvard Medical School Boston) Hyun-Chul Kim (Department of Radiology Brigham and Women’s Hospital Harvard Medical School Boston) Kavin Kowsari (Department of Radiology Brigham and Women’s Hospital Harvard Medical School Boston) Kyungho Yoon (Center for Healthcare Robotics Korea Institute of Science and Technology Seoul Korea) Yoo Seung-Schik (Department of Radiology Brigham and Women's Hospital Harvard Medical School Boston MA USA.)
저널정보
대한초음파의학회 ULTRASONOGRAPHY ULTRASONOGRAPHY Vol.41 No.2
발행연도
2022.4
수록면
382 - 393 (12page)
DOI
10.14366/usg.21186

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초록· 키워드

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Purpose: The purpose of this study was to evaluate if transcutaneous application of low-intensity ultrasound can locally enhance the effects of finasteride on hair growth in a murine model of androgenic alopecia (AA).Methods: AA mice (injected twice per week with testosterone enanthate, n=11), under daily oral administration of finasteride, received 1-MHz ultrasound for 1 hour at the unilateral thigh area five times per week for 5 weeks. Non-thermal and non-cavitational ultrasound was delivered in a pulsed manner (55-ms pulse duration with a repetition frequency of 4 Hz). Skin temperature was measured during sonication, and the measurements were validated with numerical simulations of sonication-induced tissue temperature changes. Hair growth was assessed both photographically and histologically.Results: We found more hair growth on the sonicated thigh area than on the unsonicated thigh, beginning from week 3 through the end of the experiment. Histological analyses showed that the number of hair follicles doubled in the skin sections that received sonication compared to the unsonicated zone, with thicker follicular diameter and skin. An over five-fold increase was also observed in the anagen/telogen ratio in the sonicated area, suggesting an enhanced anagen phase. Skin temperature was unaltered by the administered sonication.Conclusion: The findings of the present study suggest that pulsed application of ultrasound promotes hair growth, potentially by disrupting the binding of albumin to finasteride. This may suggest further applications to enhance the pharmacological effects of other relevant drugs exhibiting high plasma protein binding.

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