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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.9
- 수록면
- 213 - 218 (6page)
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초록· 키워드
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In order to search for anticancer agent as therapy of oral squamous cell carcinoma (OSCC) and malignant pleural mesothelioma (MPM) from Korean traditional prescriptions, we selected 58 traditional prescriptions based on a review of the Korean traditional medicine books. Among the selected traditional prescriptions, only water extracts of paedoksan (敗毒散) showed relatively good cytotoxicity at the concentration of 50 μg/ml. Additionally, we evaluated cytotoxicity for various paedoksans and each herbal ingredient in paedoksans. The root of Anthriscus sylvestris exhibited more cytotoxic effect than any other ingredients in paedoksans. Bioactivity-guided fractionation of the MC layer of Anthriscus sylvestris led to the isolation of deoxypodophyllotoxin (DPT). DPT exhibited dose-dependently significant cytotoxicity against OSCC and MPM cell with nM range. Therefore, DPT from A. sylvestris might be a potential candidate as an effective anticancer therapeutic agent for OSCC and MPM.
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참고문헌 (28)
참고문헌 신청
채정일 / 2012 / 인간 구강 편평 상피암 세포에서 Sp1단백질의 조절을 통한 Mithramycin A의 세포 사멸효과 / 대한암예방학회지 17(3):212~217
Tsao, A. S. / 2009 / Malignant pleural mesothelioma / J. Clin. Oncol 27:2081~2090
Boutin, C. / 1998 / Malignant pleural mesothelioma / Eur. Respir. J 12:972~981
Tomek, S. / 2003 / Chemotherapy for malignant pleural mesothelioma: past results and recent developments / Br. J. Cancer 88:167~174
Kim, K. H. / 2015 / Licochalcone A induces apoptosis in malignant pleural mesothelioma through downregulation of Sp1 and subsequent activation of mitochondria-related apoptotic pathway / Int. J. Oncol 46:1385~1392
Tsao, A. S. / 2009 / Malignant pleural mesothelioma / J. Clin. Oncol 27:2081~2090
Boutin, C. / 1998 / Malignant pleural mesothelioma / Eur. Respir. J 12:972~981
Tomek, S. / 2003 / Chemotherapy for malignant pleural mesothelioma: past results and recent developments / Br. J. Cancer 88:167~174
Kim, K. H. / 2015 / Licochalcone A induces apoptosis in malignant pleural mesothelioma through downregulation of Sp1 and subsequent activation of mitochondria-related apoptotic pathway / Int. J. Oncol 46:1385~1392
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