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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.6
- 수록면
- 77 - 83 (7page)
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The number of people suffering from diabetes have been increased around the world. In this study, we investigated the antidiabetic and antioxidant effects of Anthriscus sylvestris(L.) Hoffm and its main compounds. It was divided into root(R) and aerial part(AP) for comparative analysis. Total polyphenol, total flavonoid content was higher in AP extract, but nodakenin content was higher in R(1169.13 ± 6.00 ㎎/g) extract. Antioxidant activity was also higher in AP extract. To compare antidiabetic efficacy, we analyzed the effects of R and AP extracts on ɑ-glucosidase inhibition(AGI), dipeptidyl peptidase-4(DPP-4) and protein tyrosine phosphatase(PTP)1B activity. R and AP extracts showed similar effects on AGI and DPP-4 activity in a concentration dependent manner, and there was no effect on PTP1B activation. Glucose uptake(139.51 ± 3.19%) in 3T3-L1 cells was more effective in the AP extract-treated group than the positive control, rosiglitazone, group. Both R and AP extracts were effective in protecting against pancreatic beta cell damage caused by hyperglycemia. These results suggest that Anthriscus sylvestris(L.) Hoffm. could be used as a candidate for diabetes treatment.
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Abstract
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참고문헌 (19)
참고문헌 신청
Association, A. D. / 2021 / Introduction: Standards of medical care in diabetes-2021
Jugran, A. K. / 2021 / Diabetes and plant-derived natural products : From ethnopharmacological approaches to their potential for modern drug discovery and development / Phytother Res 35:223~245
Plunkett, G. M. / 1996 / Evolutionary patterns in apiaceae : inferences based on matK sequence data / Syst Bot 21:477~495
홍준호 / 2021 / 국내산 전호잎 추출물의 기능성 원료 표준화를 위한 지표성분 Cynaroside의 RP-HPLC 분석법 유효성 검증 / 한국식품영양과학회지 50(4):395~402
정승일 / 2013 / 자화전호(紫花前胡), 백화전호(白花前胡), 아삼(峨參)의 화학 성분 비교 / 한약정보연구회지(韓藥情報硏究會誌) 1(1):3~24
Jugran, A. K. / 2021 / Diabetes and plant-derived natural products : From ethnopharmacological approaches to their potential for modern drug discovery and development / Phytother Res 35:223~245
Plunkett, G. M. / 1996 / Evolutionary patterns in apiaceae : inferences based on matK sequence data / Syst Bot 21:477~495
홍준호 / 2021 / 국내산 전호잎 추출물의 기능성 원료 표준화를 위한 지표성분 Cynaroside의 RP-HPLC 분석법 유효성 검증 / 한국식품영양과학회지 50(4):395~402
정승일 / 2013 / 자화전호(紫花前胡), 백화전호(白花前胡), 아삼(峨參)의 화학 성분 비교 / 한약정보연구회지(韓藥情報硏究會誌) 1(1):3~24
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