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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.3
- 수록면
- 10 - 17 (8page)
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Ursi Fel`s component ursodeoxycholic acid (UDCA), a traditional medicine, is used for the treatment of hepatic diseases. UDCA derivatives prepared by conjugation with antioxidant moiety such as maltol, sesamol, eugenol, mesitol and 3,4- (methylenedeoxy)aniline were expected to have various biological activity caused by synergistic effect of UDCA. Therefore, in this study, it was conducted the study of the manufacture of the UDCA derivatives and their biological activity. As a result, UDCA derivatives showed weak antioxidant activity in TBA method in vitro compared to original agents. SJ-505, SJ-502 and SJ-504 showed the effect of reducing ALT, AST, sorbitol dehydrogenase and γ-glutamyltransferase in CCl₄-induced liver injury experiment in vivo, even if the effects are weaker than UDCA and silymarin of the control group.
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참고문헌 (32)
참고문헌 신청
Halliwell B / 1991 / Drug antioxidant effects. A basis for drug selection? / Drugs 42:569~605
Ceratti, P. A. / 1994 / Oxy-radicals and cancer / Lancet 344:862~863
Schwarz, K. B. / 1996 / Oxidative stress during viral infection:A review / Free Radic. Biol. Med 21:641~649
Moon, J. O. / 1997 / Screening of the hepatoprotective drugs from folk medicines / Kor. J. Pharmacogn 28:156~161
Kang, J. K. / 2001 / Single dose oral toxicity study of a new hepatotherapeutic agent GODEX (HEPADIF-S) in rats / J. Appl. Pharmacol 9:140~142
Ceratti, P. A. / 1994 / Oxy-radicals and cancer / Lancet 344:862~863
Schwarz, K. B. / 1996 / Oxidative stress during viral infection:A review / Free Radic. Biol. Med 21:641~649
Moon, J. O. / 1997 / Screening of the hepatoprotective drugs from folk medicines / Kor. J. Pharmacogn 28:156~161
Kang, J. K. / 2001 / Single dose oral toxicity study of a new hepatotherapeutic agent GODEX (HEPADIF-S) in rats / J. Appl. Pharmacol 9:140~142
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