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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 306 - 312 (7page)
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초록· 키워드
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In a previous study, we have demonstrated that S-methylmethionine sulfonium (SMMS) confers wound-healing and photoprotective effects on the skin, suggesting that SMMS can be used as a cosmetic raw material. However, it has an unpleasant odor. Therefore, in the present study, we synthesized odor-free SMMS derivatives by eliminating dimethyl sulfide, which is the cause of the unpleasant odor and identified two derivatives that exhibited skin-protective effects: one derivative comprised (2S,4S)- and (2R,4S)-2-phenylthiazolidine-4-carboxylic acid and the other comprised (2S,4R)-, (2S,4S)-, (2R,4R)-, and (2R,4S)-2-phenyl-1,3-thiazinane-4-carboxylic acid. We performed in vitro proliferation assays using human dermal fibroblasts (hDFs) and an immortalized human keratinocyte cell line (HaCaT). The two SMMS derivatives were shown to increase hDF and HaCaT cell proliferation as well as improve their survival by protecting against ultraviolet exposure. Moreover, the derivatives regulated the expression of collagen type I and MMP mRNAs against ultraviolet exposure in hDFs, suggesting that these derivatives can be developed as cosmetic raw materials.
목차
등록된 정보가 없습니다.
참고문헌 (23)
참고문헌 신청
Aliabadi, A. / 2010 / Synthesis and biological evaluation of 2-phenylthiazole-4-carboxamide derivatives as anticancer agents / Eur. J. Med. Chem. 45:5384~5389
Cheney, G. / 1949 / Rapid healing of peptic ulcers in patients receiving fresh cabbage juice / Calif. Med. 70:10~15
Gezginci-Oktayoglu, S. / 2016 / Vitamin U has a protective effect on valproic acid- induced renal damage due to its anti-oxidant, anti-inflammatory, and anti-fibrotic properties / Protoplasma 253:127~135
Hattula, T. / 1974 / Formation of dimethyl sulphide from S-methylmethionine in onion seedlings (Allium cepa) / J. Sci. Food Agric. 25:1517~1521
Kim, J. H. / 2011 / The pivotal role of reactive oxygen species generation in the hypoxia-induced stimulation of adipose-derived stem cells / Stem Cells Dev. 20:1753~1761
Cheney, G. / 1949 / Rapid healing of peptic ulcers in patients receiving fresh cabbage juice / Calif. Med. 70:10~15
Gezginci-Oktayoglu, S. / 2016 / Vitamin U has a protective effect on valproic acid- induced renal damage due to its anti-oxidant, anti-inflammatory, and anti-fibrotic properties / Protoplasma 253:127~135
Hattula, T. / 1974 / Formation of dimethyl sulphide from S-methylmethionine in onion seedlings (Allium cepa) / J. Sci. Food Agric. 25:1517~1521
Kim, J. H. / 2011 / The pivotal role of reactive oxygen species generation in the hypoxia-induced stimulation of adipose-derived stem cells / Stem Cells Dev. 20:1753~1761
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