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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 33 - 38 (6page)
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Background: Periodontitis is an inflammatory disease characterized by the breakdown of tooth-supporting tissues, leading to tooth loss. Aggregatibacter actinomycetemcomitans are major etiologic bacterium causing aggressive periodontitis.
Ursodeoxycholic acid (UDCA), a hydrophilic gall bladder acid, has been used as an effective drug for various diseases related to immunity. The aim of this study was to investigate the effect of UDCA on the inflammatory response induced by A. actinomycetemcomitans.
Methods: A human acute monocytic leukemia cell line (THP-1) was differentiated to macrophage- like cells by treatment with phorbol 12-mystristate 13-acetate (PMA) and used for all experiments. The cytotoxic effect of UDCA was examined by MTT assay. THP-1 cells were pretreated with UDCA for 30 min before A. actinomycetemcomitans infection and the culture supernatant was analyzed for various cytokine production by ELISA. The effect of UDCA on bacterial growth was examined by measuring optical densities using a spectrophotometer.
Results: UDCA showed no cytotoxic effect on THP-1 cells, up to 80 μM Ed highlight: Please confirm technical meaning.
UDCA pretreatment inhibited the A. actinomycetemcomitansinduced IL-1β, TNF-⍺, and IL-17A secretion in a dosedependent manner. UDCA also inhibited IL-21 production at 60 μM. The production of IL-12 and IL-4 was not influenced by A. actinomycetemcomitans infection.
Conclusion: These findings indicate that UDCA inhibits the production of inflammatory cytokines involved in innate and Th17 immune responses in A. actinomycetemcomitansinfected THP-1- derived macrophages, which suggests its possible use for the control of aggressive periodontitis.
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참고문헌 (23)
참고문헌 신청
Ali Cekici / 2014 / Inflammatory and immune pathways in the pathogenesis of periodontal disease / Periodontology 2000 64 (1) : 57 ~ 80
Anders Johansson / 2011 / Aggregatibacter actinomycetemcomitans Leukotoxin: A Powerful Tool with Capacity to Cause Imbalance in the Host Inflammatory Response / Toxins 3 (3)
Avaneendra Talwar / 2011 / T-helper cells in the etiopathogenesis of periodontal disease: A mini review / Journal of Indian Society of Periodontology 15 (1) : 4 ~ 10
Bruce J. Shenker / 2015 / Aggregatibacter actinomycetemcomitans Cytolethal Distending Toxin Activates the NLRP3 Inflammasome in Human Macrophages, Leading to the Release of
Dutzan, N / 2012 / Interleukin-21 expression and its association with proinflammatory cytokines in untreated chronic periodontitis patients / J Periodontol 83 (7) : 948 ~ 95
Anders Johansson / 2011 / Aggregatibacter actinomycetemcomitans Leukotoxin: A Powerful Tool with Capacity to Cause Imbalance in the Host Inflammatory Response / Toxins 3 (3)
Avaneendra Talwar / 2011 / T-helper cells in the etiopathogenesis of periodontal disease: A mini review / Journal of Indian Society of Periodontology 15 (1) : 4 ~ 10
Bruce J. Shenker / 2015 / Aggregatibacter actinomycetemcomitans Cytolethal Distending Toxin Activates the NLRP3 Inflammasome in Human Macrophages, Leading to the Release of
Dutzan, N / 2012 / Interleukin-21 expression and its association with proinflammatory cytokines in untreated chronic periodontitis patients / J Periodontol 83 (7) : 948 ~ 95
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