지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 547 - 555 (9page)
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초록· 키워드
오류제보하기
Background/Aims: Cholecystectomy is necessary for the treatment of symptomatic or complicated gallbladder (GB) stones, but oral litholysis with bile acids is an attractive alternative therapeutic option for asymptomatic or mildly symptomatic patients. This study was conducted to evaluate the efficacy of magnesium trihydrate of ursodeoxycholic acid (UDCA) and chenodeoxycholic acid (CDCA) on gallstone dissolution and to investigate improvements in gallstone-related symptoms. Methods: A prospective, multicenter, phase 4 clinical study to determine the efficacy of orally administered magnesium trihydrate of UDCA and CDCA was performed from January 2011 to June 2013. The inclusion criteria were GB stone diameter ≤15 mm, GB ejection fraction ≥50%, radiolucency on plain X-ray, and asymptomatic/mildly symptomatic patients. The patients were prescribed one capsule of magnesium trihydrate of UDCA and CDCA at breakfast and two capsules at bedtime for 6 months. The dissolution rate, response rate, and change in symptom score were evaluated. Results: A total of 237 subjects were enrolled, and 195 subjects completed the treatment. The dissolution rate was 45.1% and the response rate was 47.2% (92/195) after 6 months of administration of magnesium trihydrate of UDCA and CDCA. Only the stone diameter was significantly associated with the response rate. Both the symptom score and the number of patients with symptoms significantly decreased regardless of stone dissolution. Adverse events necessitating discontinuation of the drug, surgery, or endoscopic management occurred in 2.5% (6/237) of patients. Conclusions: Magnesium trihydrate of UDCA and CDCA is a well-tolerated bile acid that showed similar efficacy for gallstone dissolution and improvement of gallstone-related symptoms as that shown in previous studies.
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등록된 정보가 없습니다.
참고문헌 (26)
참고문헌 신청
Baron RL / 1988 / CT evaluation of gallstones in vitro: correlation with chemical analysis / AJR Am J Roentgenol 151 : 1123 ~ 1128
Bateson MC / 1981 / Calcification of radiolucent gall stone during treatment with ursodeoxycholic acid / Br Med J 283 : 645 ~ 646
Bell GD / 1972 / Gallstone dissolution in man using chenodeoxycholic acid / Lancet 2 : 1213 ~ 1216
Bell GD / 1975 / The value of radiology in predicting gallstone type when selecting patients for medical treatment / Gut 16 : 359 ~ 364
Danzinger RG / 1972 / Dissolution of cholesterol gallstones by chenodeoxycholic acid / N Engl J Med 286 : 1 ~ 8
Bateson MC / 1981 / Calcification of radiolucent gall stone during treatment with ursodeoxycholic acid / Br Med J 283 : 645 ~ 646
Bell GD / 1972 / Gallstone dissolution in man using chenodeoxycholic acid / Lancet 2 : 1213 ~ 1216
Bell GD / 1975 / The value of radiology in predicting gallstone type when selecting patients for medical treatment / Gut 16 : 359 ~ 364
Danzinger RG / 1972 / Dissolution of cholesterol gallstones by chenodeoxycholic acid / N Engl J Med 286 : 1 ~ 8
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