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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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Background: Bile acids have anti-cancer properties in a certain types of cancers. We determined anticancer activity and its underlying molecular mechanism of ursodeoxycholic acid (UDCA) in human DU145 prostate cancer cells. Methods: Cell viability was measured with an MTT assay. UDCA-induced apoptosis was determined with flow cytometric analysis. The expression levels of apoptosis-related signaling proteins were examined with Western blotting. Results: UDCA treatment significantly inhibited cell growth of DU145 in a dose-dependent manner. It induced cellular shrinkage and cytoplasmic blebs and accumulated the cells with sub-G1 DNA contents. Moreover, UDCA activated caspase 8, suggesting that UDCA-induced apoptosis is associated with extrinsic pathway. Consistent to this finding, UDCA increased the expressions of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) receptor, death receptor 4 (DR4) and death receptor 5 (DR5), and TRAIL augmented the UDCA-induced cell death in DU145 cells. In addition, UDCA also increased the expressions of Bax and cytochrome c and decreased the expression of Bcl-xL in DU145 cells. This finding suggests that UDCA-induced apoptosis may be involved in intrinsic pathway. Conclusions: UDCA induces apoptosis via extrinsic pathway as well as intrinsic pathway in DU145 prostate cancer cells. UDCA may be a promising anti-cancer agent against prostate cancer.
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참고문헌 (15)
참고문헌 신청
Mahon KL / 2011 / Pathways of chemotherapy resistance in castration-resistant prostate cancer / Endocr Relat Cancer 18:R103~R123
Lefebvre P / 2009 / Role of bile acids and bile acid receptors in metabolic regulation / Physiol Rev 89:147~191
Thomas C / 2008 / Bile acids and the membrane bile acid receptor TGR5--connecting nutrition and metabolism / Thyroid 18:167~174
Goldberg AA / 2013 / Bile acids induce apoptosis selectively in androgen-dependent and -independent prostate cancer cells / PeerJ 1:e122
Lim SC / 2011 / Lipid raft-dependent death receptor 5 (DR5) expression and activation are critical for ursodeoxycholic acid-induced apoptosis in gastric cancer cells / Carcinogenesis 32:723~731
Lefebvre P / 2009 / Role of bile acids and bile acid receptors in metabolic regulation / Physiol Rev 89:147~191
Thomas C / 2008 / Bile acids and the membrane bile acid receptor TGR5--connecting nutrition and metabolism / Thyroid 18:167~174
Goldberg AA / 2013 / Bile acids induce apoptosis selectively in androgen-dependent and -independent prostate cancer cells / PeerJ 1:e122
Lim SC / 2011 / Lipid raft-dependent death receptor 5 (DR5) expression and activation are critical for ursodeoxycholic acid-induced apoptosis in gastric cancer cells / Carcinogenesis 32:723~731
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