지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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초록· 키워드
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Primary sclerosing cholangitis (PSC) and primary biliary cholangitis (PBC) are immunemediated chronic liver diseases. PSC is a rare disorder characterized by multi-focal bile duct strictures and progressive liver diseases, in which liver transplantation is required ultimately in most patients. Imaging studies such as magnetic resonance cholangiopancreatography have important role in diagnosis in most cases of PSC. PSC is usually accompanied by inflammatory bowel disease and there is a high risk of cholangiocarcinoma and colorectal cancer in PSC. No medical therapies have been proven to delay progression of PSC. Endoscopic intervention for tissue diagnosis or biliary drainage is frequently required in cases of PSC with dominant stricture, acute cholangitis, or clinically suspected cholangiocarcinoma. PBC is a chronic inflammatory autoimmune cholestatic liver disease, which when untreated will culminate in endstage biliary cirrhosis requiring liver transplantation. Diagnosis is usually based on the presence of serum liver tests indicative of a cholestatic hepatitis in association with circulating antimitochondrial antibodies. Patient presentation and course can be diverse in PBC and risk stratification is important to ensure all patients receive a personalised approach to their care. Medical therapy using ursodeoxycholic acid (UDCA) or obeticholic acid (OCA) has an important role to reduce the progression to end-stage liver disease in PBC.
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참고문헌 (37)
참고문헌 신청
European Association for the Study of the Liver / 2017 / EASL clinical practice guidelines : the diagnosis and management of patients with primary biliary cholangitis / J Hepatol 67:145~172
Atsushi Tanaka / 2019 / IgG4-Related Sclerosing Cholangitis and Primary Sclerosing Cholangitis / Gut and Liver 13(3):300~307
Lazaridis KN / 2016 / Primary sclerosing cholangitis / N Engl J Med 375:1161~1170
Chapman MH / 2019 / British Society of Gastroenterology and UK-PSC guidelines for the diagnosis and management of primary sclerosing cholangitis / Gut 68:1356~1378
Karlsen TH / 2017 / Primary sclerosing cholangitis-a comprehensive review / J Hepatol 67:1298~1323
Atsushi Tanaka / 2019 / IgG4-Related Sclerosing Cholangitis and Primary Sclerosing Cholangitis / Gut and Liver 13(3):300~307
Lazaridis KN / 2016 / Primary sclerosing cholangitis / N Engl J Med 375:1161~1170
Chapman MH / 2019 / British Society of Gastroenterology and UK-PSC guidelines for the diagnosis and management of primary sclerosing cholangitis / Gut 68:1356~1378
Karlsen TH / 2017 / Primary sclerosing cholangitis-a comprehensive review / J Hepatol 67:1298~1323
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