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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.6
- 수록면
- 143 - 149 (7page)
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Grateloupia elliptica has been reported to have the proliferation effect of dermal papilla cells (DPCs), which play important roles in the regulation of hair cycle. In the present study, we examined in vitro and in vivo hair growth-promoting effect of Grateloupia elliptica. When isolated rat vibrissa follicles were treated with extract of G. elliptica, the hair-fiber lengths of the vibrissa follicles significantly increased. Furthermore, the G. elliptica extract accelerated the telogen-angen transition in C57BL/6 mice. To investigate the molecular mechanisms of the G. elliptica extract on the proliferation of DPCs, we examined the activation of wnt/β-catenin signaling which is known to regulate hair follicle development, differentiation and hair growth. The G. elliptica extract activated wnt/β-catenin signaling via the increase of β-catenin and phospho-GSK3β. In addition, the G. elliptica extract increased the level of cyclin E and CDK2, while the level of p27<SUP>kip1</SUP> was decreased. These results suggest that the the G. elliptica extract may induce hair growth by proliferation of DPCs via cell-cycle progression and the activation of Wnt/β-catenin signaling.
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참고문헌 (44)
참고문헌 신청
Price, V. H. / 1999 / Treatment of hair loss / N. Engl. J. Med. 341:964~973
Ellis, J. A. / 2002 / Androgenetic alopecia: pathogenesis and potential for therapy / Expert. Rev. Mol. Med. 4:1~11
Cotsarelis, G. / 2001 / Towards a molecular understanding of hair loss and its treatment / Trends Mol. Med. 7:293~301
Kaufman, K. D. / 1999 / Finasteride, a Type 2 5alpha-reductase inhibitor, in the treatment of men with androgenetic alopecia / Expert. Opin. Investig. Drugs 8:403~415
Kaufman, K. D. / 2002 / Androgens and alopecia / Mol. Cell Endocrinol 198:89~95
Ellis, J. A. / 2002 / Androgenetic alopecia: pathogenesis and potential for therapy / Expert. Rev. Mol. Med. 4:1~11
Cotsarelis, G. / 2001 / Towards a molecular understanding of hair loss and its treatment / Trends Mol. Med. 7:293~301
Kaufman, K. D. / 1999 / Finasteride, a Type 2 5alpha-reductase inhibitor, in the treatment of men with androgenetic alopecia / Expert. Opin. Investig. Drugs 8:403~415
Kaufman, K. D. / 2002 / Androgens and alopecia / Mol. Cell Endocrinol 198:89~95
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