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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 45 - 54 (10page)
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Background: Psoriasis is characterized by uncontrolled hyperproliferation, aberrant differentiation, and dermal infiltration of immune cells. Recent studies have reported that Wnt5a and Notch1 signaling are altered in psoriatic skin lesions. Objective: We aimed to investigate the interaction of Wnt5a with Notch 1 with respect to inflammation-mediated epidermal hyperproliferation in psoriasis. Methods: Expression of Wnt5a and Notch1 signaling-related proteins were examined in psoriatic skin biopsies. Wnt5a was upregulated in human keratinocytes by treating the cells with its recombinant form (rWnt5a). Results: In psoriatic lesions, expression of Wnt5a increased while that of Notch1 decreased when compared to that in non-lesional and normal skin. Treatment with rWnt5a increased the proliferation of keratinocytes and increased their secretion of interleukin (IL)-23, IL-12, and tumor necrosis factor (TNF)-α. Further, exposure of keratinocytes to IL-1α, TNF-α, transforming growth factor-α, and interferon-γ downregulated Notch1 as well as HES 1, which is downstream to Notch1, but increased the Wnt5a levels.
The upregulated Wnt5a in keratinocytes downregulated both Notch1 and HES1. Conclusion: Our data suggest that Wnt5a and Notch1 signaling exert counteracting influences on each other and are involved, in part, in the pathomechanism of psoriasis.
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참고문헌 (39)
참고문헌 신청
Nestle FO. / 2009 / Psoriasis / N Engl J Med 361:496~509
Reischl J. / 2007 / Increased expression of Wnt5a in psoriatic plaques / J Invest Dermatol 127:163~169
Romanowska M. / 2009 / Wnt5a exhibits layer-specific expression in adult skin, is upregulated in psoriasis, and synergizes with type 1 interferon / PLoS One 4:e5354
Gudjonsson JE. / 2010 / Evidence for altered Wnt signaling in psoriatic skin / J Invest Dermatol 130:1849~1859
Nicolas M. / 2003 / Notch1 functions as a tumor suppressor in mouse skin / Nat Genet 33:416~421
Reischl J. / 2007 / Increased expression of Wnt5a in psoriatic plaques / J Invest Dermatol 127:163~169
Romanowska M. / 2009 / Wnt5a exhibits layer-specific expression in adult skin, is upregulated in psoriasis, and synergizes with type 1 interferon / PLoS One 4:e5354
Gudjonsson JE. / 2010 / Evidence for altered Wnt signaling in psoriatic skin / J Invest Dermatol 130:1849~1859
Nicolas M. / 2003 / Notch1 functions as a tumor suppressor in mouse skin / Nat Genet 33:416~421
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