지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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Objectives: This study was conducted to evaluate the hair growth-promoting effects by Rumex japonicas Houttuyn ethanol extract (RJHEE) in C57BL/6N mice and HaCaT cells.
Methods: The hair growth effect was examined by topical application of RJHEE on the shaved dorsal skin of C57BL/6 mice. Six-week old mice were depilated and separated in 4 groups; CON (vehicle treatment), MXD (2% Minoxidil), and RJHEE (2% and 4%). The treatments were applied daily for 17 days. The hair growth was determined photographically and the hair density, thickness and length were identified by Folliscope. In dorsal skin tissue, the expression of hair growth-related protein was analyzed by Western blotting. In HaCaT cells, the cell proliferation and the protection against H₂O₂-induced cell damage by RJHEE were analyzed.
Results: Our results indicate that RJHEE promote the hair growth, hair density, thickness and length. RHE activate the Wnt/β-catenin signaling and induced the expression of cell survival-related proteins, such as pERK/ERK and Bcl-2/Bax. In HaCaT, RJHEE accelerated the cell proliferation and protected the H2O2-induced cell damage.
Conclusions: Our results strongly suggest that RJHEE promotes hair growth by regulating the activation of Wnt/β-catenin signaling and cell survival signaling and protects oxidative stress-induced hair damage. Therefore, RJHEE has a hair growth activity and can be useful for the treatment of alopecia.
Methods: The hair growth effect was examined by topical application of RJHEE on the shaved dorsal skin of C57BL/6 mice. Six-week old mice were depilated and separated in 4 groups; CON (vehicle treatment), MXD (2% Minoxidil), and RJHEE (2% and 4%). The treatments were applied daily for 17 days. The hair growth was determined photographically and the hair density, thickness and length were identified by Folliscope. In dorsal skin tissue, the expression of hair growth-related protein was analyzed by Western blotting. In HaCaT cells, the cell proliferation and the protection against H₂O₂-induced cell damage by RJHEE were analyzed.
Results: Our results indicate that RJHEE promote the hair growth, hair density, thickness and length. RHE activate the Wnt/β-catenin signaling and induced the expression of cell survival-related proteins, such as pERK/ERK and Bcl-2/Bax. In HaCaT, RJHEE accelerated the cell proliferation and protected the H2O2-induced cell damage.
Conclusions: Our results strongly suggest that RJHEE promotes hair growth by regulating the activation of Wnt/β-catenin signaling and cell survival signaling and protects oxidative stress-induced hair damage. Therefore, RJHEE has a hair growth activity and can be useful for the treatment of alopecia.
목차
Introduction
Materials and Methods
Results
Discussion
Conclusion
References
참고문헌 (41)
참고문헌 신청
Krause K / 2006 / Biology of the hair follicle : the basics / Seminars in cutaneous medicine and surgery 25(1):2~10
Magro CM / 2011 / The role of inflammation and immunity in the pathogenesis of androgenetic alopecia / J. Drugs Dermatol 10(12):1404~1411
Wadley AJ / 2013 / The interactions of oxidative stress and inflammation with vascular dysfunction in ageing: the vascular health triad / Age (Dordr) 35(3):705~718
Stenn KS / 2001 / Controls of hair follicle cycling / Physiological reviews 81(1):449~494
Yoo HG / 2007 / The additive effects of minoxidil and retinol on human hair growth in vitro / Biological & pharmaceutical bulletin 30(1):21~26
Magro CM / 2011 / The role of inflammation and immunity in the pathogenesis of androgenetic alopecia / J. Drugs Dermatol 10(12):1404~1411
Wadley AJ / 2013 / The interactions of oxidative stress and inflammation with vascular dysfunction in ageing: the vascular health triad / Age (Dordr) 35(3):705~718
Stenn KS / 2001 / Controls of hair follicle cycling / Physiological reviews 81(1):449~494
Yoo HG / 2007 / The additive effects of minoxidil and retinol on human hair growth in vitro / Biological & pharmaceutical bulletin 30(1):21~26
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