지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.12
- 수록면
- 234 - 241 (8page)
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초록· 키워드
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Dermal papilla cells (DPCs) are present throughout the hair cycle and play an essential role in hair cycle and hair growth. In this study, we investigated the effect of Carex dispalata on the activation of anagen pathway in DPCs. C. dispalata extract increased the proliferation of DPCs and induced changes in the levels of cell cycle-related proteins. To elucidate the mechanism by which C. dispalata extract stimulates the anagen pathway related to the proliferation of DPCs, we evaluated the effect of C. dispalata extract on the activation of Akt signaling. The increase in the level of phospho-Akt by C. dispalata extract was inhibited by PI3K inhibitor (wortmannin). Wortmannin reduced the effects of C. dispalata extract on the levels of cell cycle-related proteins and proliferation of DPCs. C. dispalata extract increased the levels of Wnt/β-catenin proteins. Wnt/β-catenin inhibitor ( XAV939) inhibited changes in cell cycle, cell cycle-related proteins, Wnt/β-catenin proteins, and proliferation induced by C. dispalata extract. C. dispalata extract increased the level of autophagy protein (LC3I/II), and this change was inhibited by XAV939. These results suggest that C. dispalata extract can activate PI3K/Akt, Wnt/β-catenin, and autophagy pathways in DPCs to induce cell proliferation, and thereby promote hair growth phase.
목차
Abstract
재료 및 방법
결과 및 고찰
결론
인용문헌
참고문헌 (26)
참고문헌 신청
Price, V. H. / 1999 / Treatment of hair loss / N. Engl. J. Med 341:964~973
Ellis, J. A. / 2002 / Androgenetic alopecia : pathogenesis and potential for therapy / Expert. Rev. Mol. Med 4:1~11
Kaufman, K. D. / 2002 / Androgens and alopecia / Mol. Cell Endocrinol 198:89~95
Aoki, E. / 2003 / Intermittent foot shock stress prolongs the telogen stage in the hair cycle of mice / Exp. Dermatol 12:371~377
Botchkarev, V. A. / 2003 / Molecular mechanisms of chemotherapy-induced hair loss / J. Investig. Dermatol. Symp. Proc 8:72~75
Ellis, J. A. / 2002 / Androgenetic alopecia : pathogenesis and potential for therapy / Expert. Rev. Mol. Med 4:1~11
Kaufman, K. D. / 2002 / Androgens and alopecia / Mol. Cell Endocrinol 198:89~95
Aoki, E. / 2003 / Intermittent foot shock stress prolongs the telogen stage in the hair cycle of mice / Exp. Dermatol 12:371~377
Botchkarev, V. A. / 2003 / Molecular mechanisms of chemotherapy-induced hair loss / J. Investig. Dermatol. Symp. Proc 8:72~75
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