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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 155 - 161 (7page)
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The Wnt signaling pathway has regulatory roles in cell proliferation, differentiation, andpolarity. Aberrant Wnt pathway regulation can lead to abnormal cell proliferation andcancer, and loss of Wnt7a expression has been demonstrated in lung cancer cell lines.
E-cadherin keeps intercellular integrity and prevents metastasis. Therefore, E-cadherin hasbeen known as a prognostic factor in cancer. In the present study, we investigated theE-cadherin expression status by immunohistochemical stain and the Wnt7a promotermethylation status in human non-small cell lung carcinoma (NSCLC) by methylationspecificPCR. We also analyzed their correlations with clinicopathological factors.
Methylation of the Wnt7a gene promoter was detected in the lung tissues of 32 of 121(26.4%) patients with NSCLC. Wnt7a promoter methylation was correlated with advancedtumor stage (P = 0.036) and distant metastasis (P = 0.037). In addition, Wnt7a promotermethylation showed correlation with loss of E-cadherin expression (P < 0.001). However,Wnt7a promoter methylation was not closely related with gender, age, histological type,or smoking habit. Even though Wnt7a methylation could not show significant correlationwith the long term survival of the patients with limited follow up data, these findingssuggest that loss of the Wnt7a gene induced by promoter methylation might be anotherprognostic factor for NSCLC and that restoration of Wnt7a may be a promising treatmentfor NSCLC.
Keywords: Carcin
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참고문헌 (37)
참고문헌 신청
Dubey S / 2009 / Update in lung cancer 2008 / Am J Respir Crit Care Med 179:860~868
Adjei AA / 2001 / Blocking oncogenic Ras signaling for cancer therapy / J Natl Cancer Inst 93:1062~1074
Graziano SL / 1999 / Prognostic significance of K-ras codon 12 mutations in patients with resected stage I and II non-smallcell lung cancer / J Clin Oncol 17:668~675
Hsieh ET / 2000 / Co-expression of epidermal growth factor receptor and transforming growth factor-α is independent of rasmutations in lung adenocarcinoma / Lung Cancer 29:151~157
Ohsaki Y / 2000 / Epidermal growth factor receptor expression correlates with poor prognosis in non-small cell lung cancer patients with p53 overexpression / Oncol Rep 7:603~607
Adjei AA / 2001 / Blocking oncogenic Ras signaling for cancer therapy / J Natl Cancer Inst 93:1062~1074
Graziano SL / 1999 / Prognostic significance of K-ras codon 12 mutations in patients with resected stage I and II non-smallcell lung cancer / J Clin Oncol 17:668~675
Hsieh ET / 2000 / Co-expression of epidermal growth factor receptor and transforming growth factor-α is independent of rasmutations in lung adenocarcinoma / Lung Cancer 29:151~157
Ohsaki Y / 2000 / Epidermal growth factor receptor expression correlates with poor prognosis in non-small cell lung cancer patients with p53 overexpression / Oncol Rep 7:603~607
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