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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 759 - 765 (7page)
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초록· 키워드
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Knowledge of the extent of linkage disequilibrium (LD) between markers is crucial for determining the number of markers required for quantitative trait loci mapping, genome-wide association studies, and application of marker-assisted selection. In this study, we surveyed genome-wide LD using three genotyping BeadChips (9, 50, and 80 K) in 11 indigenous Ethiopian cattle populations and the Korean (Hanwoo) cattle breed. The overall mean r2 values were 0.05 ± 0.12, 0.12 ± 0.20, and 0.20 ± 0.24 in the Ethiopian cattle populations for the 9, 50, and 80 K genotyping BeadChips, respectively. In Hanwoo cattle, these values were respectively 0.06 ± 0.13, 0.15 ± 0.23, and 0.15 ± 0.26. The level of LD was significantly affected by breed, genotyping BeadChip, and chromosome (P\0.0001). For Ethiopian cattle populations, a moderate level of LD (r2 = 0.22) extended at marker distances of 20–40 kb for the indicine-derived 80 K BeadChip, whereas it was only 0.14 for the 50 K BeadChip. As a consequence of the moderate r2, genome-wide association studies in Ethiopian cattle populations require 75,000–150,000 indicine- derived SNPs (with a MAF C 0.05). We suggest that indicine-derived SNPs maybe more suitable for genomewide association studies and genomic selection in indigenous Ethiopian (or African) cattle populations.
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등록된 정보가 없습니다.
참고문헌 (26)
참고문헌 신청
Arias JA / 2009 / A high density linkage map of the bovine genome / BMC Genet 10:18
Boichard D / 2012 / Design of a bovine low-density SNP array optimized for imputation / PLoS One 7:e34130
Hailu Dadi / 2014 / Inter- and intra-population genetic divergence of East Asian cattle populations: focusing on Korean cattle / Genes & Genomics 36(3):261~265
Edea Z / 2013 / Genetic diversity, population structure and relationships in indigenous cattle populations of Ethiopia and Korean Hanwoo breeds using SNP markers / Front Genet 4:35
Edea Z / 2014 / Linkage disequilibrium and genomic scan to detect selective loci in cattle populations adapted to different ecological conditions in Ethiopia / J Anim Breed Genet 131:358~366
Boichard D / 2012 / Design of a bovine low-density SNP array optimized for imputation / PLoS One 7:e34130
Hailu Dadi / 2014 / Inter- and intra-population genetic divergence of East Asian cattle populations: focusing on Korean cattle / Genes & Genomics 36(3):261~265
Edea Z / 2013 / Genetic diversity, population structure and relationships in indigenous cattle populations of Ethiopia and Korean Hanwoo breeds using SNP markers / Front Genet 4:35
Edea Z / 2014 / Linkage disequilibrium and genomic scan to detect selective loci in cattle populations adapted to different ecological conditions in Ethiopia / J Anim Breed Genet 131:358~366
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