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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 286 - 297 (12page)
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초록· 키워드
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Mammalian patatin-like phospholipase domain containing proteins (PNPLAs) play critical roles in triglyceride hydrolysis, phospholipids metabolism, and lipid droplet (LD) homeostasis. PNPLA7 is a lysophosphatidylcholine hydrolase anchored on the endoplasmic reticulum which associates with LDs through its catalytic region (PNPLA7-C) in response to increased cyclic nucleotide levels. However, the interaction of PNPLA7 with LDs through its catalytic region is unknown. Herein, we demonstrate that PNPLA7-C localizes to the mature LDs ex vivo and also colocalizes with pre-existing LDs. Localization of PNPLA7-C with LDs induces LDs clustering via non-enzymatic intermolecular associations, while PNPLA7 alone does not induce LD clustering. Residues 742-1016 contains four putative transmembrane domains which act as a LD targeting motif and are required for the localization of PNPLA7-C to LDs. Furthermore, the N-terminal flanking region of the LD targeting motif, residues 681-741, contributes to the LD targeting, whereas the C-terminal flanking region (1169-1326) has an anti-LD targeting effect. Interestingly, the LD targeting motif does not exhibit lysophosphatidylcholine hydrolase activity even though it associates with LDs phospholipid membranes. These findings characterize the specific functional domains of PNPLA7 mediating subcellular positioning and interactions with LDs, as wells as providing critical insights into the structure of this evolutionarily conserved phospholipid-metabolizing enzyme family.
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참고문헌 (40)
참고문헌 신청
Akassoglou, K. / 2004 / Brain-specific deletion of neuropathy target esterase/swisscheese results in neurodegeneration / Proc. Natl. Acad. Sci. U. S. A 101:5075~5080
Atkins, J. / 2000 / Membrane association of and critical residues in the catalytic domain of human neuropathy target esterase / J. Biol. Chem 275:24477~24483
Barneda, D. / 2017 / Lipid droplet growth : regulation of a dynamic organelle / Curr. Opin. Cell Biol 47:9~15
Brasaemle, D. L. / 2016 / Isolation of lipid droplets from cells by density gradient centrifugation / Curr. Protoc. Cell Biol 72:3.15.1~3.15.13
Chang, P. A. / 2012 / Identification of two novel splicing variants of murine NTE-related esterase / Gene 497:164~171
Atkins, J. / 2000 / Membrane association of and critical residues in the catalytic domain of human neuropathy target esterase / J. Biol. Chem 275:24477~24483
Barneda, D. / 2017 / Lipid droplet growth : regulation of a dynamic organelle / Curr. Opin. Cell Biol 47:9~15
Brasaemle, D. L. / 2016 / Isolation of lipid droplets from cells by density gradient centrifugation / Curr. Protoc. Cell Biol 72:3.15.1~3.15.13
Chang, P. A. / 2012 / Identification of two novel splicing variants of murine NTE-related esterase / Gene 497:164~171
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